ECSP972325A - INHIBITING AMIDES OF THE APO B / MTP SECRETION - Google Patents
INHIBITING AMIDES OF THE APO B / MTP SECRETIONInfo
- Publication number
- ECSP972325A ECSP972325A ECSP972325A ECSP972325A EC SP972325 A ECSP972325 A EC SP972325A EC SP972325 A ECSP972325 A EC SP972325A EC SP972325 A ECSP972325 A EC SP972325A
- Authority
- EC
- Ecuador
- Prior art keywords
- inhibitors
- compounds
- hmg
- useful
- apo
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
El invento se refiere a un compuesto de la fórmula I (gráfico), o a los estereosómeros, sales farmacéuticamente aceptables e hidratos de los mismos. Los compuestos son inhibidores de Apo B/MTP y son útiles en el tratamiento de diversos trastornos y afecciones tales como la aterosclerosis, la pancreatitis, la obesidad, la hipercolesterolemia, la hipertrigliceridemia, la hiperlipidemia y la diabetis. Los compuestos de esta invención también son útiles junto con otros agentes farmacéuticos que incluyen inhibidores de la biosíntesis de colesterol e inhibidores de la absorción de colesterol, especialmente inhibidores de la absorción de colesteril, especialmente inhibidores de la HMG-CoA reductasa e inhibidores de la HMG - CoA sintasa; inhibidores de la expresión genética de la HMG-CoA reductasa; inhibidores de CETP; complejantes de ácidos bilares; fibratos; inhibidores de la absorción del colesterol; inhibidores de ACT, inhibidores de la escualeno sintetasa, resinas de intercambio iónico, antioxidantes y niacina. Esta invención también está dirigida a intermedios y procedimientos útiles en la preparación de compuestos de fórmula I.The invention relates to a compound of formula I (graph), or to stereosomers, pharmaceutically acceptable salts and hydrates thereof. The compounds are Apo B / MTP inhibitors and are useful in the treatment of various disorders and conditions such as atherosclerosis, pancreatitis, obesity, hypercholesterolemia, hypertriglyceridemia, hyperlipidemia, and diabetes. The compounds of this invention are also useful in conjunction with other pharmaceutical agents including cholesterol biosynthesis inhibitors and cholesterol absorption inhibitors, especially cholesteryl absorption inhibitors, especially HMG-CoA reductase inhibitors and HMG inhibitors. - CoA synthase; inhibitors of HMG-CoA reductase gene expression; CETP inhibitors; bile acid complexing agents; fibrates; cholesterol absorption inhibitors; ACT inhibitors, squalene synthetase inhibitors, ion exchange resins, antioxidants and niacin. This invention is also directed to intermediates and procedures useful in the preparation of compounds of formula I.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP972325 ECSP972325A (en) | 1997-11-27 | 1997-11-27 | INHIBITING AMIDES OF THE APO B / MTP SECRETION |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP972325 ECSP972325A (en) | 1997-11-27 | 1997-11-27 | INHIBITING AMIDES OF THE APO B / MTP SECRETION |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP972325A true ECSP972325A (en) | 1998-12-14 |
Family
ID=42043154
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP972325 ECSP972325A (en) | 1997-11-27 | 1997-11-27 | INHIBITING AMIDES OF THE APO B / MTP SECRETION |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP972325A (en) |
-
1997
- 1997-11-27 EC ECSP972325 patent/ECSP972325A/en unknown
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