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La invención se refiere a compuestos de fórmula I: (gráfico) y a sus sales farmacéuticamente aceptables, en la que R, R1 y R2 son como se han definido en la presente invención. La invención se refiere además a composiciones farmacéuticas que contienen, y a procedimientos de utilización de los compuestos de fórmula I, o de sus sales aceptables, para inhibición de la fosfodiesterasa (PDE) tipo IV o de la producción de factor de necrosis tumoral (TNF) en un mamífero. La invención se refiere además a intermedios que resultan de utilidad en la preparación de compuesto de fórmula.The invention relates to compounds of formula I: (graph) and their pharmaceutically acceptable salts, in which R, R1 and R2 are as defined in the present invention. The invention further relates to pharmaceutical compositions containing, and methods of using the compounds of formula I, or their acceptable salts, for inhibition of type IV phosphodiesterase (PDE) or the production of tumor necrosis factor (TNF) in a mammal. The invention further relates to intermediates which are useful in the preparation of compound of formula.
DERIVED FROM THE 1, 3, 5-TRIAZINA-2, 4-DIAMINAS-6-SUBSTITUTED-N-SUBSTITUTED AND PHARMACEUTICALLY ACCEPTABLE SALTS OF THE SAME, COMPOSITIONS AND APPLICATIONS.
DERIVATIVES OF 3,4,5,7-TETRAHIDRO-PIRROLO [3 ', 4': 4,5] TIENO [2,3-d] PIRIMIDINE 3-SUBSTITUTED AND ITS USE FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS