ECSP972206A - SUBSTITUTED PYRROLES - Google Patents

Abstract

Compounds of the formula (graph), wherein R1 and R1 - independently of one another are alkyl, aryl, alkenyl or alkynyl; R2 and R2¿con are independently hydrogen, alkyl, aralkyl, alkoxyalkyl, hidroxialqluilo, haloalkyl, aminoalkyl, monoalkylaminoalkyl, dialkylaminoalkyl, acylaminoalkyl, alquilslulfonilaminoalquilo, arylsulfonyl aminoalkyl, mercaptoalkyl, alkylthioalkyl, carboxyalkyl, alcoxicarbonialquilo, amonocarbonilalquilo, alkylthio or alkylsulfinyl; R4, R5, R6, R7, R4¿, R5¿, R6¿, and R7¿ independently of each other are hydrogen. CH2OCR8, CO2R9, CH2OR10, CHO, CH2NR11R12, CON ((R13) 2 halo cyano, aryl, aralkyloxy, alkyl, hydroxy, alkoxy, aryloxy, haloalkyl, nitro, amino aralkyloxy, acylamino, monoalkylamino, dialkylamino, thio, alkylthio, alkyls, alkylsulfonyl, arylsulfinyl, azide, phosphate, or phosphonate, provided that at least one of R4, R5, R6, and R7 and at least one of R4, R5, R6, and R7 is other than hydrogen; that if R6 is motoxy, then R5 or R5 is not methoxy, R8 is alkyl or aryl; R9 is alkyl or aryl; R10 is hydrogen, alkyl or aryl; R11 and R12 independently of each other are hydrogen, alkyl, aryl, aralkyl or acyl; R12 is hydrogen, alkyl, aryl or aralkyl; and one of X is Y means O and the other means OS (H, OH) or (H, H); as well as the pharmaceutically acceptable pre-products of the acidic compounds of formula I with bases or basic compounds of formula I with acids are useful antiproliferative agents for the treatment of cancer.