ECSP972206A - SUBSTITUTED PYRROLES - Google Patents

SUBSTITUTED PYRROLES

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Publication number
ECSP972206A
ECSP972206A ECSP972206A ECSP972206A EC SP972206 A ECSP972206 A EC SP972206A EC SP972206 A ECSP972206 A EC SP972206A EC SP972206 A ECSP972206 A EC SP972206A
Authority
EC
Ecuador
Prior art keywords
alkyl
aryl
hydrogen
independently
aralkyl
Prior art date
Application number
Other languages
Spanish (es)
Inventor
Donna Mary Huryn
Urvashi Hooda Dhingra
Dennis Dalton Keith
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to ECSP972206 priority Critical patent/ECSP972206A/en
Publication of ECSP972206A publication Critical patent/ECSP972206A/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Los compuestos de la fórmula (gráfico), en la que R1 y R1¿con independencia entre si son alquilo, arilo, alquenilo o alquinilo; R2 y R2¿con independencia entre si son hidrógeno, alquilo, aralquilo, alcoxialquilo, hidroxialqluilo, haloalquilo, aminoalquilo, monoalquilaminoalquilo, dialquilaminoalquilo, acilaminoalquilo, alquilslulfonilaminoalquilo, arilsulfonil-aminoalquilo, mercaptoalquilo, alquiltioalquilo, carboxialquilo, alcoxicarbonialquilo, amonocarbonilalquilo, alquiltio o alquilsulfinilo; R4, R5, R6, R7, R4¿, R5¿, R6¿, Y R7¿con independencia entre si son hidrógeno. CH2OCR8, CO2R9, CH2OR10, CHO, CH2NR11R12, CON((R13)2 halógeno ciano, arilo, aralquiloxi, alquilo, hidroxi, alcoxi, ariloxi, haloalquilo, nitro, amino aralquiloxi, acilamino, monoalquiamino, dialquilamino, tio, alquiltio, alquilsulfinilo, alquilsulfonilo, arilsulfinilo, azida, fosfato o fosfonato, con la condición de que por lo menos uno de R4, R5, R6, Y R7 y por lo menos uno de R4, R5, R6 y R7 sea distinto de hidrógeno; con la condición de que si R6 es motoxi, entonces R5 o R5¿no sea metoxi, R8 es alquilo o arilo; R9 es alquilo o arilo; R10 es hidrógeno, alquilo o arilo; R11 y R12 con independencia entre si son hidrógeno, alquilo, arilo, aralquilo o acilo; R12 es hidrógeno, alquilo, arilo o aralquilo; y uno de X es Y significa O y el otro significa O.S.(H,OH) o (H,H); así como los productos previos farmacéuticamente aceptables de los compuestos ácidos de la fórmula I con bases o de los compuestos básicos de la fórmula I con ácidos, son agentes antiproliferativos útiles para el tratamiento del cáncer.Compounds of the formula (graph), wherein R1 and R1 - independently of one another are alkyl, aryl, alkenyl or alkynyl; R2 and R2¿con are independently hydrogen, alkyl, aralkyl, alkoxyalkyl, hidroxialqluilo, haloalkyl, aminoalkyl, monoalkylaminoalkyl, dialkylaminoalkyl, acylaminoalkyl, alquilslulfonilaminoalquilo, arylsulfonyl aminoalkyl, mercaptoalkyl, alkylthioalkyl, carboxyalkyl, alcoxicarbonialquilo, amonocarbonilalquilo, alkylthio or alkylsulfinyl; R4, R5, R6, R7, R4¿, R5¿, R6¿, and R7¿ independently of each other are hydrogen. CH2OCR8, CO2R9, CH2OR10, CHO, CH2NR11R12, CON ((R13) 2 halo cyano, aryl, aralkyloxy, alkyl, hydroxy, alkoxy, aryloxy, haloalkyl, nitro, amino aralkyloxy, acylamino, monoalkylamino, dialkylamino, thio, alkylthio, alkyls, alkylsulfonyl, arylsulfinyl, azide, phosphate, or phosphonate, provided that at least one of R4, R5, R6, and R7 and at least one of R4, R5, R6, and R7 is other than hydrogen; that if R6 is motoxy, then R5 or R5 is not methoxy, R8 is alkyl or aryl; R9 is alkyl or aryl; R10 is hydrogen, alkyl or aryl; R11 and R12 independently of each other are hydrogen, alkyl, aryl, aralkyl or acyl; R12 is hydrogen, alkyl, aryl or aralkyl; and one of X is Y means O and the other means OS (H, OH) or (H, H); as well as the pharmaceutically acceptable pre-products of the acidic compounds of formula I with bases or basic compounds of formula I with acids are useful antiproliferative agents for the treatment of cancer.

ECSP972206 1997-07-28 1997-07-28 SUBSTITUTED PYRROLES ECSP972206A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ECSP972206 ECSP972206A (en) 1997-07-28 1997-07-28 SUBSTITUTED PYRROLES

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ECSP972206 ECSP972206A (en) 1997-07-28 1997-07-28 SUBSTITUTED PYRROLES

Publications (1)

Publication Number Publication Date
ECSP972206A true ECSP972206A (en) 1998-09-22

Family

ID=42043036

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP972206 ECSP972206A (en) 1997-07-28 1997-07-28 SUBSTITUTED PYRROLES

Country Status (1)

Country Link
EC (1) ECSP972206A (en)

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