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La presente invención presenta proteínas, polipéptidos, secuencias de ácido nucléico, construcciones, vectores de expresión, células huésped, composiciones farmacéuticas de bicunina placentaria humana, dominios de inhibición de la serina proteasa, y fragmentos de los mismos, y métodos para usarlos.The present invention presents proteins, polypeptides, nucleic acid sequences, constructs, expression vectors, host cells, pharmaceutical compositions of human placental bicunin, serine protease inhibition domains, and fragments thereof, and methods of using them.