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Pharmaceuticals Containing Other Organic And Inorganic Compounds
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Acyclic And Carbocyclic Compounds In Medicinal Compositions
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Medicinal Preparation
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Abstract
Compuestos de (4-oxi-3-(aril)fenil)-azarilo o -arilcaboniloxi, en la forma libre o de sal de adición de ácido, son útiles como productos farmacéuticos para el tratamiento y profilaxis de la inflamación; particularmente enfermedades inflamatorias u obstructivas de las vías respiratorias, por ejemplo, para terapia del asma. Los compuestos preferidos son nuevos compuestos de bifenil piridinas, bifenil benzamidas y fibenil fenilcarboxi. Los compuestos son inhibidores selectivos de la actividad de isoenzima PDE4 y también actúan para regular en descenso o inhibir la liberación de TNF-a(4-Oxy-3- (aryl) phenyl) -azaryl or -arylcabonyloxy compounds, in the free or acid addition salt form, are useful as pharmaceuticals for the treatment and prophylaxis of inflammation; particularly inflammatory or obstructive airway diseases, for example, for asthma therapy. Preferred compounds are new compounds of biphenyl pyridines, biphenyl benzamides and fibenyl phenylcarboxy. The compounds are selective inhibitors of PDE4 isoenzyme activity and also act to down-regulate or inhibit TNF-a release.
A PHARMACEUTICAL COMPOSITION, A COMPOUND OF (4-OXI-3- (ARYL) FENYL) -AZARYL OR -ARYL CARBONYLLOX, IN THE FREE OR SALT FORM OF ACIDOFARMACEUTICALLY ACCEPTABLE COMPOSITION FOR SUCH COMPOSITION, A COMPARED PROCESS FOR SUCH COMPOSITION INTERMEDIARIES EMPLOYED IN SUCH PROCESS
compounds, process for their preparation, pharmaceutical compositions comprising them, method for treating and / or prophylaxis of diseases and use of such compounds
DERIVATIVES OF 5-PHENYL-4-METHYL-TIAZOL-2-IL-AMINA AS INHIBITORS OF KINASA ENZYMES PHOSFATIDILINOSITOL 3 (PI3) FOR THE TREATMENT OF INFLAMMATORY DISEASES OF THE RESPIRATORY ROUTES