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Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
La presente invención proporciona compuestos de fórmula (gráfico) y sales de adición de ácido farmacéuticamente aceptables del mismo, en la que X es un enlace directo o alquileno C1 - C4 y R es cicloalquilo C3 - C7, opcionalmente sustituido por 1 ó 2 sustituyentes seleccionados cada uno independientemente entre fluoro y cicloalquilo C3 - C7, a condición de que X no es metileno cuando R es ciclopropilo, junto con procedimientos para la preparación de, intermedios usados en la preparación de, composiciones que contienen y usos de, tales compuestos. Estos compuestos son útiles como antagonistas de taquiquininas.The present invention provides compounds of the formula (graph) and pharmaceutically acceptable acid addition salts thereof, wherein X is a direct bond or C1-C4 alkylene and R is C3-C7 cycloalkyl, optionally substituted by 1 or 2 selected substituents each independently between fluoro and C3-C7 cycloalkyl, provided that X is not methylene when R is cyclopropyl, together with procedures for the preparation of intermediates used in the preparation of, compositions containing, and uses of, such compounds. These compounds are useful as tachykinin antagonists.
ADENOSINE A2A RECEIVING ANTAGONISTS OF 5-AMINO- [1,2,4] -BICYCLIC TRIAZOL, PHARMACEUTICAL COMPOSITIONS THAT INCLUDE THEM, THE USE OF THE SAME, ONLY OR IN COMBINATION OF THE COMPOUNDS AND OTHER AGENTS FOR THE PREPARATION OF MEDICINES UTI THE TREATMENT OF PARKINSON'S DISEASE AND A
CORTICOTROPIN RELEASE FACTOR THIOPHENOPYRIDINE ANTAGONISTS. PROCEDURE FOR ITS PREPARATION, THE USE OF THE SAME IN THE PREPARATION OF A MEDICINAL PRODUCT, PHARMACEUTICAL COMPOSITION THAT INCLUDES THEM, PROCEDURE FOR THE PREPARATION OF SUCH COMPOSITION, AN INTERMEDIATE COMPOUND AND
COMPOUNDS DERIVED FROM UREIDO PIPERIDINA, PROCEDURE FOR OBTAINING THEM, INTERMEDIATE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THE USE OF THE SAME FOR THE PREPARATION OF MEDICINES