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El invento se refiere a las 4-mercapto-benzoilguanidinas de fórmula I en la que A, R1,R2 y R3 tienen los significados indicados en la reivindicación 1, y a sus sales aceptables desde el punto de vista fisiológico. También se refiere a un procedimiento para preparar dichos compuestos a preparaciones farmacéuticas que los contienen y al empleo de los mismos para el tratamiento de las arritmias, de la angina de pecho, infartos y también para el tratamiento preventivo de estas enfermedades. Los nuevos compuestos del invento poseen propiedades antiarrítmicas y un efecto inhibidor del mecanismo de intercambio de Na+/H+ de las células.The invention relates to the 4-mercapto-benzoylguanidines of formula I in which A, R1, R2 and R3 have the meanings indicated in claim 1, and to their physiologically acceptable salts. It also refers to a process for preparing said compounds to pharmaceutical preparations containing them and to the use of the same for the treatment of arrhythmias, angina, heart attacks and also for the preventive treatment of these diseases. The new compounds of the invention possess antiarrhythmic properties and an inhibitory effect on the Na + / H + exchange mechanism of cells.
ECSP9616521996-01-301996-01-30
DERIVATIVES FROM 4- MERCAPTO-BENZOILGUANIDINE
ECSP961652A
(en)
ORIS BISARILO COMPOUNDS, META-SUBSTITUTES, PROCEDURES FOR THEIR PREPARATION, ITS USE AS A MEDICINAL PRODUCT AS ALSO THE PHARMACEUTICAL PREPARATIONS CONTAINING THEM
BENCILOXICARBONYLGUANIDINES REPLACED AS INHIBITORS OF THE SODIUM PROTECTOR EXCHANGER, PROCEDURE FOR ITS PREPARATION, ITS USE AS A MEDICINAL PRODUCT OR DIAGNOSTIC AGENT, AS WELL AS A MEDICINAL PRODUCT CONTAINING THEM.
2-(butyl-1-sulfonylamino)-n-[1(r)-(6-methoxy-pyridin-3-yl)-propyl]-benzamid, the use thereof in the form of drug an pharmaceutical preparations containing said compound
DERIVATIVES FROM 4-AMINO-BENZOYLGUANIDINE, A PROCEDURE TO PREPARE THEM, THEIR USE OF THEM TO PREPARE A MEDICINAL PRODUCT, THE PHARMACEUTICAL PREPARATIONS CONTAINING THEM, AND A PROCEDURE TO PREPARE THESE PHARMACEUTICAL PREPARATIONS.