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El invento se refiere a un procedimiento para la separación de los isómeros r-(+) y s-(-) de la amodipina a partir de sus mezclas, que comprende la reacción de la mezcla e isómeros con acido l- o -tartarico en un disolvente orgánico que contiene dimetil sulfoxido (dmso) suficiente para la precipitación de respectivamente un solvato de dmso de una sal de l-tartrato de la r-(+)-amlodipina, o un solvato de dmso de una sal de d-tartrato de la s-(-)-amlodipina.The invention relates to a process for separating the r - (+) and s - (-) isomers of amodipine from their mixtures, which comprises the reaction of the mixture and isomers with l- or -tartaric acid in an organic solvent containing dimethyl sulfoxide (dmso) sufficient for the precipitation of respectively a dmso solvate of a l-tartrate salt of r - (+) - amlodipine, or a dmso solvate of a d-tartrate salt of s - (-) - amlodipine.
ECSP9514121995-03-231995-03-23
SEPARATION OF AMLODIPINE ENANTIOMERS
ECSP951412A
(en)
USE OF A PHARMACEUTICALLY ACCEPTABLE SALT OF (3R, 2'R) -3 - ((CICLOPENTILHYDROXIFENILACETIL) OXI) -1,1-DIMETHYL PIRROLIDINY FOR THE PREPARATION OF A MEDICINAL PRODUCT.
Process for the separation of the two optical isomers of 1-(o-methoxyphenoxy)-3-isopropylamino-propan-2-ol, optical isomers obtained thereby and pharmaceutical compositions of the levorotatory antipode thereof.