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Publication of ECSP941064ApublicationCriticalpatent/ECSP941064A/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Furan Compounds
(AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof
(AREA)
Abstract
Un procedimiento para preparar clorhidrato de ranitidina Forma 1, caracterizado porque comprende: formar una solución de clorhidrato de ranitidina en un solvente mixto, que comprende por lo menos un alcanol de 1 a 4 átomos de carbono y un hidrocarburo aromático de 6 a 10 átomos de carbono, siendo la relación en volumen de uno o varios alcanoles al hidrocarburo, de aproximadamente 1:1 a 1:2; e iniciar la cristalización del clorhidrato de ranitidina Forma 1 de dicha solución, en presencia de cristales de siembra de clorhidrato de ranitidina puro, Forma I.A process for preparing ranitidine hydrochloride Form 1, characterized in that it comprises: forming a solution of ranitidine hydrochloride in a mixed solvent, comprising at least one alkanol of 1 to 4 carbon atoms and an aromatic hydrocarbon of 6 to 10 carbon atoms. carbon, the volume ratio of one or more alkanols to the hydrocarbon being approximately 1: 1 to 1: 2; and starting the crystallization of ranitidine hydrochloride Form 1 of said solution, in the presence of seed crystals of pure ranitidine hydrochloride, Form I.
ECSP9410641993-07-071994-04-04
PREPARATION OF RANITIDINE CHLORHYDRATE FORM 1
ECSP941064A
(en)
SODIUM SALT OF AN HIV INTEGRAS INHIBITOR, PROCESSES FOR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING IT AND ITS USE FOR THE MANUFACTURE OF A MEDICINAL PRODUCT