ECSP18019949A - CYCLIC DINUCLEOTIDE COMPOUNDS AS STING AGONISTS - Google Patents

CYCLIC DINUCLEOTIDE COMPOUNDS AS STING AGONISTS

Info

Publication number
ECSP18019949A
ECSP18019949A ECIEPI201819949A ECPI201819949A ECSP18019949A EC SP18019949 A ECSP18019949 A EC SP18019949A EC IEPI201819949 A ECIEPI201819949 A EC IEPI201819949A EC PI201819949 A ECPI201819949 A EC PI201819949A EC SP18019949 A ECSP18019949 A EC SP18019949A
Authority
EC
Ecuador
Prior art keywords
cyclic dinucleotide
sting agonists
compounds
dinucleotide compounds
general formula
Prior art date
Application number
ECIEPI201819949A
Other languages
Spanish (es)
Inventor
Andresen Brian
Wesley Trotter Benjamin
D Otte Ryan
Zhao Kake
N Cumming Jared
P Jewell James
Liu Hong
Siu Tony
Liang Rui
Marc Haidle Andrew
P Walsh Shawn
Lloyd Childers Matthew
J Henderson Timothy
D Altman Michael
B Northrup Alan
Lu Min
T Truong Quang
Chang Wonsuk
Lim Jongwon
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of ECSP18019949A publication Critical patent/ECSP18019949A/en

Links

Abstract

Se proporciona una clase de compuestos policíclicos de fórmula general (I), de fórmula general (I'), o de fórmula general (II''), en las que Base1 , Base2 , Y, Ya , Xa , Xa1, Xb , Xb1, Xc , Xc1 , X d , Xd1, R1 , R1a, R2 , R2a, R3 , R4 , R4a, R5 , R6 , R6a, R7 , R7a, R8 y R8a se definen en el presente documento, que pueden ser útiles como inductores de la producción de interferones de tipo I, específicamente como agentes activos de STING. También se proporcionan procesos de síntesis y de uso de compuestos.A class of polycyclic compounds of general formula (I), general formula (I '), or general formula (II' ') is provided, wherein Base1, Base2, Y, Ya, Xa, Xa1, Xb, Xb1 , Xc, Xc1, X d, Xd1, R1, R1a, R2, R2a, R3, R4, R4a, R5, R6, R6a, R7, R7a, R8 and R8a are defined herein, which may be useful as inducers of the production of type I interferons, specifically as active agents of STING. Processes for synthesis and use of compounds are also provided.

ECIEPI201819949A 2015-08-13 2018-03-13 CYCLIC DINUCLEOTIDE COMPOUNDS AS STING AGONISTS ECSP18019949A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562204677P 2015-08-13 2015-08-13

Publications (1)

Publication Number Publication Date
ECSP18019949A true ECSP18019949A (en) 2018-07-31

Family

ID=60451227

Family Applications (1)

Application Number Title Priority Date Filing Date
ECIEPI201819949A ECSP18019949A (en) 2015-08-13 2018-03-13 CYCLIC DINUCLEOTIDE COMPOUNDS AS STING AGONISTS

Country Status (2)

Country Link
AR (1) AR105683A1 (en)
EC (1) ECSP18019949A (en)

Also Published As

Publication number Publication date
AR105683A1 (en) 2017-11-01

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ECSP18019949A (en) CYCLIC DINUCLEOTIDE COMPOUNDS AS STING AGONISTS