ECSP14033496A - THIAZOLS SUBSTITUTED BY CARBOXAMIDE OR SULFONAMIDE AND RELATED DERIVATIVES AS MODULATORS FOR THE ROR [GAMMA] ORPHAN NUCLEAR RECEPTOR - Google Patents

THIAZOLS SUBSTITUTED BY CARBOXAMIDE OR SULFONAMIDE AND RELATED DERIVATIVES AS MODULATORS FOR THE ROR [GAMMA] ORPHAN NUCLEAR RECEPTOR

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Publication number
ECSP14033496A
ECSP14033496A ECIEPI201433496A ECPI201433496A ECSP14033496A EC SP14033496 A ECSP14033496 A EC SP14033496A EC IEPI201433496 A ECIEPI201433496 A EC IEPI201433496A EC PI201433496 A ECPI201433496 A EC PI201433496A EC SP14033496 A ECSP14033496 A EC SP14033496A
Authority
EC
Ecuador
Prior art keywords
gamma
ror
modulators
sulfonamide
nuclear receptor
Prior art date
Application number
ECIEPI201433496A
Other languages
Spanish (es)
Inventor
Christoph Steeneck
Christian Gege
Olaf Kinzel
Gerald Kleymann
Thomas Hoffmann
Original Assignee
Phenex Pharmaceuticals Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Phenex Pharmaceuticals Ag filed Critical Phenex Pharmaceuticals Ag
Publication of ECSP14033496A publication Critical patent/ECSP14033496A/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La invención provee moduladores para el receptor nuclear huérfano ROR[gamma] y métodos para tratar enfermedades mediadas por ROR[gamma] mediante la administración de estos moduladores novedosos de ROR[gamma] a un humano o mamífero que los necesite. Específicamente, la presente invención provee compuestos cíclicos que contienen carboxamida o sulfonamida de Fórmula (1), (1'), (100), (100'), (200) y (200'), y los enantiómeros, diastereómeros, tautómeros, N-óxidos, solvatos y sales farmacéuticamente aceptables de los mismos.The invention provides modulators for the orphan nuclear receptor ROR [gamma] and methods of treating ROR [gamma] mediated diseases by administering these novel modulators of ROR [gamma] to a human or mammal in need thereof. Specifically, the present invention provides cyclic carboxamide or sulfonamide-containing compounds of Formula (1), (1 '), (100), (100'), (200) and (200 '), and the enantiomers, diastereomers, tautomers, N-oxides, solvates and pharmaceutically acceptable salts thereof.

ECIEPI201433496A 2012-05-31 2014-12-30 THIAZOLS SUBSTITUTED BY CARBOXAMIDE OR SULFONAMIDE AND RELATED DERIVATIVES AS MODULATORS FOR THE ROR [GAMMA] ORPHAN NUCLEAR RECEPTOR ECSP14033496A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261653556P 2012-05-31 2012-05-31
EP12004186 2012-05-31

Publications (1)

Publication Number Publication Date
ECSP14033496A true ECSP14033496A (en) 2015-09-30

Family

ID=71943845

Family Applications (1)

Application Number Title Priority Date Filing Date
ECIEPI201433496A ECSP14033496A (en) 2012-05-31 2014-12-30 THIAZOLS SUBSTITUTED BY CARBOXAMIDE OR SULFONAMIDE AND RELATED DERIVATIVES AS MODULATORS FOR THE ROR [GAMMA] ORPHAN NUCLEAR RECEPTOR

Country Status (2)

Country Link
EC (1) ECSP14033496A (en)
PE (1) PE20200480A1 (en)

Also Published As

Publication number Publication date
PE20200480A1 (en) 2020-03-03

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