Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filedlitigationCriticalhttps://patents.darts-ip.com/?family=52634062&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP12012358(A)"Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp & DohmefiledCriticalMerck Sharp & Dohme
Publication of ECSP12012358ApublicationCriticalpatent/ECSP12012358A/en
Un compuesto de fórmula I o una sal farmacéuticamente aceptable de la misma, son capaces de modular la producción del cuerpo del guanosín monofosfato cíclico (GMPc) y son generalmente adecuados para la terapia y profilaxis de las enfermedades que están asociadas con un equilibrio perturbado del GMPc. La invención se refiere además a los procesos para preparar compuestos de fórmula I o una sal farmacéuticamente aceptable del mismo, para su uso en la terapia y profilaxis de las enfermedades arriba mencionadas y para la preparación de productos farmacéuticos destinados a este fin, y a preparaciones farmacéuticas que comprendan compuestos de Fórmula I o una sal farmacéuticamente aceptable de los mismos.A compound of formula I or a pharmaceutically acceptable salt thereof, are capable of modulating the body production of cyclic guanosine monophosphate (cGMP) and are generally suitable for the therapy and prophylaxis of diseases that are associated with a disturbed cGMP balance. . The invention further relates to the processes for preparing compounds of formula I or a pharmaceutically acceptable salt thereof, for use in the therapy and prophylaxis of the above-mentioned diseases and for the preparation of pharmaceutical products intended for this purpose, and to pharmaceutical preparations. comprising compounds of Formula I or a pharmaceutically acceptable salt thereof.
DERIVATIVES OF 4-AMINO-2- (1H-PIRAZOLO [3,4-B] PIRIDINA-3-IL) -6-OXO-6,7-DIHIDRO-5H-PIRROLO [2,3-D] PYRIMIDINE AND RESPECTIVES DERIVATIVES OF (1H-INDAZOL-3-IL) AS CGMP MODULATORS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES
DERIVATIVES OF ESTRA 1,3,5 (10), 16 TETRAENE 3 SUBSTITUTES, METHODS FOR THEIR PREPARATION, PHARMACEUTICAL PREPARATIONS CONTAINING THEM, AS WELL AS THEIR USE FOR THE PREPARATION OF MEDICINES