ECSP11011413A - Inhibidores cíclicos de 11beta-hidroxiesteroide deshidrogenasa 1 - Google Patents

Inhibidores cíclicos de 11beta-hidroxiesteroide deshidrogenasa 1

Info

Publication number
ECSP11011413A
ECSP11011413A EC2011011413A ECSP11011413A ECSP11011413A EC SP11011413 A ECSP11011413 A EC SP11011413A EC 2011011413 A EC2011011413 A EC 2011011413A EC SP11011413 A ECSP11011413 A EC SP11011413A EC SP11011413 A ECSP11011413 A EC SP11011413A
Authority
EC
Ecuador
Prior art keywords
11beta
cyclic inhibitors
hydroxiesteroid
dehydrogenase
cortisol
Prior art date
Application number
EC2011011413A
Other languages
English (en)
Inventor
Martin Renz
Zhenrong Xu
Martin Schuele
Original Assignee
Vitae Pharmaceuticals Inc
Boheringer Ingelheim Internat
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2009/002653 external-priority patent/WO2009134400A1/en
Priority claimed from PCT/US2009/004261 external-priority patent/WO2010011314A1/en
Priority claimed from PCT/US2010/033157 external-priority patent/WO2010127237A2/en
Application filed by Vitae Pharmaceuticals Inc, Boheringer Ingelheim Internat filed Critical Vitae Pharmaceuticals Inc
Publication of ECSP11011413A publication Critical patent/ECSP11011413A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

Esta invención se refiere a nuevos compuestos de la Fórmula Ik, Im1, Im2, Im5, In1, In2, In5, Io1, Io2, Io5, Ip1, Ip3, a sales farmacéuticamente aceptables de los mismos y a composiciones farmacéuticas de los mismos, que son útiles para el tratamiento terapéutico de enfermedades asociadas con la modulación o inhibición de 11 -HSD1 en mamíferos. La invención también se refiere a composiciones farmacéuticas de los nuevos compuestos y métodos para su uso en la reducción o control de la producción de cortisol en una célula o la inhibición de la conversión de cortisona en cortisol en una célula.
EC2011011413A 2009-04-30 2011-10-21 Inhibidores cíclicos de 11beta-hidroxiesteroide deshidrogenasa 1 ECSP11011413A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/US2009/002653 WO2009134400A1 (en) 2008-05-01 2009-04-30 Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
PCT/US2009/004261 WO2010011314A1 (en) 2008-07-25 2009-07-23 Cyclic inhibitors of 11 beta-hydroxysteroid dehydrogenase 1
PCT/US2010/033157 WO2010127237A2 (en) 2009-04-30 2010-04-30 Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1

Publications (1)

Publication Number Publication Date
ECSP11011413A true ECSP11011413A (es) 2012-01-31

Family

ID=44583523

Family Applications (2)

Application Number Title Priority Date Filing Date
EC2011010839A ECSP11010839A (es) 2009-07-23 2011-02-18 Inhibidores cíclicos de 11beta-hidroxiesteroide deshidrogenasa 1
EC2011011413A ECSP11011413A (es) 2009-04-30 2011-10-21 Inhibidores cíclicos de 11beta-hidroxiesteroide deshidrogenasa 1

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EC2011010839A ECSP11010839A (es) 2009-07-23 2011-02-18 Inhibidores cíclicos de 11beta-hidroxiesteroide deshidrogenasa 1

Country Status (7)

Country Link
EP (1) EP2424865B1 (es)
AR (1) AR076492A1 (es)
AU (1) AU2010242876B2 (es)
EC (2) ECSP11010839A (es)
NZ (1) NZ618741A (es)
TN (1) TN2011000031A1 (es)
TW (1) TW201040167A (es)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR067673A1 (es) * 2007-07-26 2009-10-21 Vitae Pharmaceuticals Inc Derivados de 1,3 oxazinan - 2 - ona como inhibidores ciclicos de la 11 beta -hidroxiesteroide deshidrogenasa 1. composiciones farmaceuticas.
US8846668B2 (en) * 2008-07-25 2014-09-30 Vitae Pharmaceuticals, Inc. Inhibitors of 11beta-hydroxysteroid dehydrogenase 1

Also Published As

Publication number Publication date
AR076492A1 (es) 2011-06-15
EP2424865A2 (en) 2012-03-07
NZ618741A (en) 2015-05-29
ECSP11010839A (es) 2011-03-31
AU2010242876A1 (en) 2011-10-20
AU2010242876B2 (en) 2015-06-18
EP2424865B1 (en) 2017-01-18
TN2011000031A1 (en) 2012-09-05
TW201040167A (en) 2010-11-16

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