ECSP099738A - PIRAZOLONA DERIVATIVES AS PDE4 INHIBITORS - Google Patents
PIRAZOLONA DERIVATIVES AS PDE4 INHIBITORSInfo
- Publication number
- ECSP099738A ECSP099738A EC2009009738A ECSP099738A ECSP099738A EC SP099738 A ECSP099738 A EC SP099738A EC 2009009738 A EC2009009738 A EC 2009009738A EC SP099738 A ECSP099738 A EC SP099738A EC SP099738 A ECSP099738 A EC SP099738A
- Authority
- EC
- Ecuador
- Prior art keywords
- pirazolona
- derivatives
- pde4 inhibitors
- inhibitors
- phosphodiesterase
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4152—1,2-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. antipyrine, phenylbutazone, sulfinpyrazone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Otolaryngology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Transplantation (AREA)
- Gastroenterology & Hepatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Gynecology & Obstetrics (AREA)
Abstract
Los compuestos de cierta fórmula (1), en los cuales R1, R7, R8, R9 y n tienen los significados que se les dan en la descripción, y son inhibidores novedosos efectivos de la fosfodiesterasa de tipo 4.The compounds of a certain formula (1), in which R1, R7, R8, R9 and n have the meanings given in the description, and are effective novel inhibitors of type 4 phosphodiesterase.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07108314 | 2007-05-16 | ||
| PCT/EP2008/055867 WO2008138939A1 (en) | 2007-05-16 | 2008-05-14 | Pyrazolone derivatives as pde4 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP099738A true ECSP099738A (en) | 2009-12-28 |
Family
ID=38179942
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2009009738A ECSP099738A (en) | 2007-05-16 | 2009-11-13 | PIRAZOLONA DERIVATIVES AS PDE4 INHIBITORS |
Country Status (31)
| Country | Link |
|---|---|
| US (3) | US8304436B2 (en) |
| EP (3) | EP2402330B1 (en) |
| JP (2) | JP5529010B2 (en) |
| KR (1) | KR101601284B1 (en) |
| CN (2) | CN103463086B (en) |
| AR (1) | AR066576A1 (en) |
| AT (1) | ATE526326T1 (en) |
| AU (1) | AU2008250069B2 (en) |
| BR (1) | BRPI0811214A2 (en) |
| CA (1) | CA2686909C (en) |
| CO (1) | CO6220956A2 (en) |
| CY (1) | CY1112152T1 (en) |
| DK (1) | DK2148876T3 (en) |
| EA (1) | EA018984B1 (en) |
| EC (1) | ECSP099738A (en) |
| ES (2) | ES2374337T3 (en) |
| HK (2) | HK1141017A1 (en) |
| HR (1) | HRP20110940T1 (en) |
| IL (1) | IL201959A (en) |
| ME (1) | ME00952B (en) |
| MX (1) | MX2009012062A (en) |
| MY (1) | MY154498A (en) |
| NZ (1) | NZ581547A (en) |
| PL (1) | PL2148876T3 (en) |
| PT (1) | PT2148876E (en) |
| RS (1) | RS52074B (en) |
| SI (1) | SI2148876T1 (en) |
| TW (2) | TWI414521B (en) |
| UA (1) | UA100019C2 (en) |
| WO (1) | WO2008138939A1 (en) |
| ZA (1) | ZA200906423B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2374337T3 (en) * | 2007-05-16 | 2012-02-15 | Nycomed Gmbh | DERIVATIVES OF PIRAZOLONA AS INHIBITORS OF PDE4. |
| AR074318A1 (en) * | 2008-11-14 | 2011-01-05 | Nycomed Gmbh | HETEROCICLIC DERIVATIVES OF PIRAZOLONA, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND USE OF THE SAME FOR THE TREATMENT OF DISEASES OF RESPIRATORY ROADS. |
| EP2404902A1 (en) * | 2009-03-05 | 2012-01-11 | Shionogi&Co., Ltd. | Piperidine and pyrrolidine derivatives having npy y5 receptor antagonism |
| WO2011136752A1 (en) * | 2010-04-26 | 2011-11-03 | Mahmut Bilgic | Combined pharmaceutical composition comprising carmoterol and ciclesonide for the treatment of respiratory diseases |
| JP5609614B2 (en) * | 2010-12-15 | 2014-10-22 | 東ソー株式会社 | Novel arylamine dendrimer-like compound, production method thereof and use thereof |
| US10202366B2 (en) | 2013-03-15 | 2019-02-12 | Karyopharm Therapeutics Inc. | Methods of promoting wound healing using CRM1 inhibitors |
| WO2021245192A1 (en) | 2020-06-04 | 2021-12-09 | Topadur Pharma Ag | Novel dual mode of action soluble guanylate cyclase activators and phosphodiesterase inhibitors and uses thereof |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2903460A (en) | 1956-04-07 | 1959-09-08 | Sandoz Ag | Pyrazolone derivatives |
| US4550119A (en) | 1983-05-23 | 1985-10-29 | Warner-Lambert Company | 2,4-Dihydro-5-[(substituted)phenyl]-4,4-disubstituted-3H-pyrazol-3-ones |
| IE71647B1 (en) | 1991-01-28 | 1997-02-26 | Rhone Poulenc Rorer Ltd | Benzamide derivatives |
| ATE282025T1 (en) | 1992-07-28 | 2004-11-15 | Aventis Pharma Ltd | INHIBITORS OF C-AMP PHOSPHODIESTERASE |
| AU687087B2 (en) | 1993-07-02 | 1998-02-19 | Takeda Gmbh | Fluoroalkoxy-substituted benzamides and their use as cyclic nucleotide phosphodiesterase inhibitors |
| MX9700557A (en) | 1994-07-22 | 1997-12-31 | Byk Gulden Lomberg Chem Fab | Dihydrobenzofuranes. |
| ATE233247T1 (en) * | 1997-01-15 | 2003-03-15 | Altana Pharma Ag | PHTALAZINONES |
| US6418201B1 (en) | 2000-02-22 | 2002-07-09 | Intel Corporation | Multiple platform voice processing system with optimized resource allocation |
| EE05386B1 (en) | 2001-02-15 | 2011-02-15 | ALTANA�Pharma�AG | Phthalazinone Piperidine Derivatives, ÁnendeAutomationAjaArmedication |
| AU2002234836B2 (en) | 2001-04-20 | 2007-08-23 | Pfizer Products Inc. | Process for the preparation of 1,3-substituted indenes and aryl-fused azapolycyclic compounds |
| CA2445233A1 (en) | 2001-04-25 | 2002-10-31 | Altana Pharma Ag | Phthalazinones derivatives useful as pde4/7 inhibitors |
| WO2004018457A1 (en) | 2002-08-10 | 2004-03-04 | Altana Pharma Ag | Pyrrolidinedione substituted piperidine-phthalazones as pde4 inhibitors |
| US20060167001A1 (en) | 2002-08-10 | 2006-07-27 | Sterk Jan G | Pyridazinone-derivatives as pde4 inhibitors |
| WO2004018449A1 (en) * | 2002-08-10 | 2004-03-04 | Altana Pharma Ag | Piperidine-derivatives as pde4 inhibitors |
| CA2496732A1 (en) * | 2002-08-20 | 2004-03-04 | Biosurface Engineering Technologies, Inc. | Synthetic heparin-binding growth factor analogs |
| CA2537185A1 (en) * | 2003-08-29 | 2005-03-10 | Ranbaxy Laboratories Limited | Inhibitors of phosphodiesterase type-iv |
| WO2005075457A1 (en) | 2004-02-04 | 2005-08-18 | Altana Pharma Ag | Phthalazinone-derivatives as pde4 inhibitors |
| JP4778449B2 (en) | 2004-02-04 | 2011-09-21 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | 2- (Piperidin-4-yl) -4,5-dihydro-2H-pyridazin-3-one derivatives as PDE4 inhibitors |
| JP2006169138A (en) * | 2004-12-14 | 2006-06-29 | Kyorin Pharmaceut Co Ltd | Pyrazolopyridinepyrazolone derivative, its acid addition salt and pde inhibitor |
| ES2374337T3 (en) * | 2007-05-16 | 2012-02-15 | Nycomed Gmbh | DERIVATIVES OF PIRAZOLONA AS INHIBITORS OF PDE4. |
-
2008
- 2008-05-14 ES ES08759563T patent/ES2374337T3/en active Active
- 2008-05-14 EP EP11182678.0A patent/EP2402330B1/en active Active
- 2008-05-14 WO PCT/EP2008/055867 patent/WO2008138939A1/en active Application Filing
- 2008-05-14 US US12/451,348 patent/US8304436B2/en not_active Expired - Fee Related
- 2008-05-14 JP JP2010507909A patent/JP5529010B2/en not_active Expired - Fee Related
- 2008-05-14 CA CA2686909A patent/CA2686909C/en not_active Expired - Fee Related
- 2008-05-14 MX MX2009012062A patent/MX2009012062A/en active IP Right Grant
- 2008-05-14 ES ES11182678T patent/ES2427442T3/en active Active
- 2008-05-14 CN CN201310349480.8A patent/CN103463086B/en not_active Expired - Fee Related
- 2008-05-14 DK DK08759563.3T patent/DK2148876T3/en active
- 2008-05-14 AU AU2008250069A patent/AU2008250069B2/en not_active Ceased
- 2008-05-14 PL PL08759563T patent/PL2148876T3/en unknown
- 2008-05-14 KR KR1020097025745A patent/KR101601284B1/en not_active IP Right Cessation
- 2008-05-14 ME MEP-2009-327A patent/ME00952B/en unknown
- 2008-05-14 SI SI200830491T patent/SI2148876T1/en unknown
- 2008-05-14 EP EP08759563A patent/EP2148876B1/en active Active
- 2008-05-14 RS RS20110570A patent/RS52074B/en unknown
- 2008-05-14 CN CN2008800119475A patent/CN101657441B/en not_active Expired - Fee Related
- 2008-05-14 EP EP12174018A patent/EP2508520A1/en not_active Withdrawn
- 2008-05-14 MY MYPI20094317A patent/MY154498A/en unknown
- 2008-05-14 UA UAA200912770A patent/UA100019C2/en unknown
- 2008-05-14 EA EA200901504A patent/EA018984B1/en not_active IP Right Cessation
- 2008-05-14 NZ NZ581547A patent/NZ581547A/en not_active IP Right Cessation
- 2008-05-14 BR BRPI0811214-2A2A patent/BRPI0811214A2/en active Search and Examination
- 2008-05-14 PT PT08759563T patent/PT2148876E/en unknown
- 2008-05-14 AT AT08759563T patent/ATE526326T1/en active
- 2008-05-15 AR ARP080102055A patent/AR066576A1/en not_active Application Discontinuation
- 2008-05-16 TW TW097118165A patent/TWI414521B/en not_active IP Right Cessation
- 2008-05-16 TW TW102129216A patent/TWI460174B/en not_active IP Right Cessation
-
2009
- 2009-09-15 ZA ZA200906423A patent/ZA200906423B/en unknown
- 2009-10-16 CO CO09115665A patent/CO6220956A2/en active IP Right Grant
- 2009-11-05 IL IL201959A patent/IL201959A/en not_active IP Right Cessation
- 2009-11-13 EC EC2009009738A patent/ECSP099738A/en unknown
-
2010
- 2010-08-03 HK HK10107416.9A patent/HK1141017A1/en not_active IP Right Cessation
-
2011
- 2011-12-15 HR HR20110940T patent/HRP20110940T1/en unknown
- 2011-12-20 CY CY20111101261T patent/CY1112152T1/en unknown
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2012
- 2012-09-14 US US13/618,026 patent/US8865745B2/en not_active Expired - Fee Related
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2014
- 2014-04-16 JP JP2014084704A patent/JP5850972B2/en not_active Expired - Fee Related
- 2014-05-28 HK HK14105008.3A patent/HK1191574A1/en not_active IP Right Cessation
- 2014-08-29 US US14/473,338 patent/US9090597B2/en not_active Expired - Fee Related
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