ECSP099192A - SPECIFIC HUMAN MONOCLONAL ANTIBODIES FOR HUMAN LIGHT ANTAGONISTS - Google Patents
SPECIFIC HUMAN MONOCLONAL ANTIBODIES FOR HUMAN LIGHT ANTAGONISTSInfo
- Publication number
- ECSP099192A ECSP099192A ECSP099192A ECSP099192A EC SP099192 A ECSP099192 A EC SP099192A EC SP099192 A ECSP099192 A EC SP099192A EC SP099192 A ECSP099192 A EC SP099192A
- Authority
- EC
- Ecuador
- Prior art keywords
- hlight
- antibodies
- fully human
- polypeptide
- immunospecifically
- Prior art date
Links
Landscapes
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Se proporcionan aquí anticuerpos, como por ejemplo anticuerpos totalmente humanos, que se unen inmunoespecíficamente a un polipéptido hLIGHT. Se proporcionan también ácidos nucleicos aislados que codifican anticuerpos, como por ejemplo anticuerpos totalmente humanos que se unen inmunoespecíficamente a un polipéptido hLIGHT. Se proporcionan además vectores y células hospederas que comprenden anticuerpos que codifican ácidos nucleicos, como por ejemplo anticuerpos totalmente humanos, que se unen inmunoespecíficamente a un polipéptido hLIGHT. Se proporcionan también métodos para preparar anticuerpos, como por ejemplo anticuerpos totalmente humanos, que se unen inmunoespecíficamente a un polipéptido hLIGHT. Se proporciona también aquí un método para tratar una enfermedad mediada por hLIGHT en un sujeto, que comprende la administración al sujeto de un anticuerpo, como por ejemplo un anticuerpo totalmente humano, que se une inmunoespecíficamente a un polipéptido hLIGHT. En modalidades preferidas, los anticuerpos anti-hLIGHT proporcionados aquí mejoran, neutralizan o inhiben de otra forma la actividad biológica hLIGHT in vivo (por ejemplo, la producción o secreción mediada por hLIGHT de CCL20, IL-8 o RANTES a partir de una célula que expresa un receptor hLIGHT). Se proporciona también aquí un método para detectar hLIGHT en una muestra así como un método para mejorar, neutralizar o inhibir de otra forma la actividad hLIGHT, por ejemplo, en un sujeto humano que padece de una enfermedad en donde la actividad hLIGHT es perjudicial.Antibodies, such as fully human antibodies, which bind immunospecifically to an hLIGHT polypeptide are provided herein. Isolated nucleic acids encoding antibodies are also provided, such as fully human antibodies that immunospecifically bind to an hLIGHT polypeptide. In addition, vectors and host cells comprising antibodies encoding nucleic acids, such as fully human antibodies, that bind immunospecifically to an hLIGHT polypeptide are provided. Methods for preparing antibodies, such as fully human antibodies, that bind immunospecifically to an hLIGHT polypeptide are also provided. A method is also provided here for treating a hLIGHT mediated disease in a subject, which comprises administering to the subject an antibody, such as a fully human antibody, that binds immunospecifically to an hLIGHT polypeptide. In preferred embodiments, the anti-hLIGHT antibodies provided herein enhance, neutralize or otherwise inhibit hLIGHT biological activity in vivo (eg, hLIGHT-mediated production or secretion of CCL20, IL-8 or RANTES from a cell that expresses an hLIGHT receiver). A method is also provided here to detect hLIGHT in a sample as well as a method to improve, neutralize or otherwise inhibit hLIGHT activity, for example, in a human subject suffering from a disease where hLIGHT activity is detrimental.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84077406P | 2006-08-28 | 2006-08-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP099192A true ECSP099192A (en) | 2009-06-30 |
Family
ID=41057664
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP099192 ECSP099192A (en) | 2006-08-28 | 2009-03-19 | SPECIFIC HUMAN MONOCLONAL ANTIBODIES FOR HUMAN LIGHT ANTAGONISTS |
Country Status (6)
| Country | Link |
|---|---|
| CN (1) | CN101663321B (en) |
| EC (1) | ECSP099192A (en) |
| HN (1) | HN2009000414A (en) |
| SI (1) | SI2292663T1 (en) |
| UA (1) | UA99714C2 (en) |
| ZA (1) | ZA200901165B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201701194D0 (en) * | 2017-01-24 | 2017-03-08 | Capella Bioscience Ltd | Antigen binding molecules that bind light |
| MX2022011811A (en) * | 2020-04-01 | 2022-10-07 | Avalo Therapeutics Inc | Methods and treatment involving excess free light. |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL136113A0 (en) * | 1997-11-14 | 2001-05-20 | Euro Celtique Sa | Modified antibodies with enhanced ability to elicit an anti-idiotype response |
-
2007
- 2007-08-24 CN CN200780040270.3A patent/CN101663321B/en active Active
- 2007-08-24 SI SI200731379T patent/SI2292663T1/en unknown
- 2007-08-24 UA UAA200902921A patent/UA99714C2/en unknown
- 2007-08-24 ZA ZA200901165A patent/ZA200901165B/en unknown
-
2009
- 2009-02-27 HN HN2009000414A patent/HN2009000414A/en unknown
- 2009-03-19 EC ECSP099192 patent/ECSP099192A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN101663321B (en) | 2014-10-08 |
| SI2292663T1 (en) | 2014-02-28 |
| ZA200901165B (en) | 2010-06-30 |
| UA99714C2 (en) | 2012-09-25 |
| HN2009000414A (en) | 2012-02-17 |
| CN101663321A (en) | 2010-03-03 |
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