ECSP088354A - HUMAN MONOCLONAL ANTIBODIES FOR KINASE-1 ACTIVINE RECEPTOR TYPE - Google Patents

HUMAN MONOCLONAL ANTIBODIES FOR KINASE-1 ACTIVINE RECEPTOR TYPE

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Publication number
ECSP088354A
ECSP088354A ECSP088354A ECSP088354A EC SP088354 A ECSP088354 A EC SP088354A EC SP088354 A ECSP088354 A EC SP088354A EC SP088354 A ECSP088354 A EC SP088354A
Authority
EC
Ecuador
Prior art keywords
antibodies
alk
relates
kinase
receptor type
Prior art date
Application number
Other languages
Spanish (es)
Inventor
Sirid Aimee Kellermann
Michael North
Karin Kristina Amundson
Shelley Sims Belousky
Dana Dan Hu-Lowe
Xin Jiang
Shannan Marie Karlicek
James Arthur Thomson
Jianying Wang
Grant Raymond Wickman
Jingchuan Zhang
Original Assignee
Amgen Fremont Inc
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Fremont Inc, Pfizer filed Critical Amgen Fremont Inc
Publication of ECSP088354A publication Critical patent/ECSP088354A/en

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  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

. .La presente invención se relaciona a los anticuerpos que incluyen anticuerpos humanos y a las porciones aglutinantes de antígeno de los mismos, que aglutinan el dominio extracelular ALK ( SD) V de la quinasa-1 (ALK-1) tipo receptor de activita y esa función que abroga la trayectoria de señalización ALK-1 /TGF -veta-1/Smad1. La invención se relaciona también a las inmunoglobulinas de cadenas pesada y liviana, procedente de los anticuerpos anti-ALK-1 humanos, y a las moléculas de ácido nucleico que codifican tales inmunoglobulinas. La presente invención se relaciona también a métodos para hacer los anticuerpos anti-ALK-1, humanos, composiciones que consisten de estos anticuerpos y los métodos para el uso de los anticuerpos y las composiciones. La invención se relaciona también a los animales y plantas transgénicos que consisten de moléculas de ácido nucleico de la presente invención. The present invention relates to antibodies that include human antibodies and the antigen binding portions thereof, which bind the extracellular domain ALK (SD) V of kinase-1 (ALK-1) activite receptor type and that function which repeals the signaling path ALK-1 / TGF -veta-1 / Smad1. The invention also relates to heavy and light chain immunoglobulins, derived from human anti-ALK-1 antibodies, and to nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods for making human anti-ALK-1 antibodies, compositions consisting of these antibodies and methods for the use of antibodies and compositions. The invention also relates to transgenic animals and plants consisting of nucleic acid molecules of the present invention.

ECSP088354 2005-09-07 2008-04-07 HUMAN MONOCLONAL ANTIBODIES FOR KINASE-1 ACTIVINE RECEPTOR TYPE ECSP088354A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US15292705P 2005-09-07 2005-09-07

Publications (1)

Publication Number Publication Date
ECSP088354A true ECSP088354A (en) 2008-05-30

Family

ID=40434929

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP088354 ECSP088354A (en) 2005-09-07 2008-04-07 HUMAN MONOCLONAL ANTIBODIES FOR KINASE-1 ACTIVINE RECEPTOR TYPE

Country Status (1)

Country Link
EC (1) ECSP088354A (en)

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