ECSP066618A - METHOD FOR IMPROVING THE EFFECTIVENESS OF RADIOOTULATED THERAPEUTIC DRUGS - Google Patents

METHOD FOR IMPROVING THE EFFECTIVENESS OF RADIOOTULATED THERAPEUTIC DRUGS

Info

Publication number
ECSP066618A
ECSP066618A EC2006006618A ECSP066618A ECSP066618A EC SP066618 A ECSP066618 A EC SP066618A EC 2006006618 A EC2006006618 A EC 2006006618A EC SP066618 A ECSP066618 A EC SP066618A EC SP066618 A ECSP066618 A EC SP066618A
Authority
EC
Ecuador
Prior art keywords
improving
radiootulated
effectiveness
drug
therapeutic drugs
Prior art date
Application number
EC2006006618A
Other languages
Spanish (es)
Inventor
Werner Krause
Original Assignee
Schering Akti Engesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Akti Engesellschaft filed Critical Schering Akti Engesellschaft
Publication of ECSP066618A publication Critical patent/ECSP066618A/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/08Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0038Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/08Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1027Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/08Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1045Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
    • A61K51/1069Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell being from blood cells, e.g. the cancer being a myeloma
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Optics & Photonics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Se dan a conocer drogas radiorotuladas y métodos para mejorar su eficacia mediante el uso de un radiosensibilizador tal que el radiosensibilizador tanto forma parte de la droga radiorotulada mediante el acople directo del radiosensibilizador a la droga radiorotulada como produciendo una mezcla de la droga radiorotulada y un análogo de la droga con el radiosensibilizador acoplado a la droga en lugar del radiorótulo.Radio-labeled drugs and methods for improving their efficacy are disclosed through the use of a radiosensitizer such that the radiosensitizer is both part of the radio-labeled drug by direct coupling of the radiosensitizer to the radio-labeled drug and producing a mixture of the radio-labeled drug and an analogue. of the drug with the radiosensitizer coupled to the drug instead of the radiograph.

EC2006006618A 2003-12-11 2006-06-08 METHOD FOR IMPROVING THE EFFECTIVENESS OF RADIOOTULATED THERAPEUTIC DRUGS ECSP066618A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US52847303P 2003-12-11 2003-12-11

Publications (1)

Publication Number Publication Date
ECSP066618A true ECSP066618A (en) 2006-10-25

Family

ID=34676848

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2006006618A ECSP066618A (en) 2003-12-11 2006-06-08 METHOD FOR IMPROVING THE EFFECTIVENESS OF RADIOOTULATED THERAPEUTIC DRUGS

Country Status (14)

Country Link
EP (1) EP1691838A2 (en)
JP (1) JP2007528874A (en)
KR (1) KR20060118542A (en)
CN (1) CN101031319A (en)
AU (1) AU2004296621A1 (en)
BR (1) BRPI0417517A (en)
CA (1) CA2546057A1 (en)
CR (1) CR8439A (en)
EC (1) ECSP066618A (en)
IL (1) IL175674A0 (en)
MX (1) MXPA06006683A (en)
NO (1) NO20063207L (en)
RU (1) RU2006124510A (en)
WO (1) WO2005056058A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI568453B (en) * 2011-11-22 2017-02-01 原創生醫股份有限公司 A drug carrier with chelating complex micelles and the application thereof
CN106975078B (en) * 2017-03-31 2020-11-10 国家纳米科学中心 Application of nano material containing gadolinium polytungstate as sensitizer
WO2024013272A1 (en) * 2022-07-13 2024-01-18 Universite De Montpellier Combined therapy with nanoparticles and radiopharmaceuticals

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR022404A1 (en) * 1999-01-25 2002-09-04 Photogen Inc METHOD AND AGENTS FOR IMPROVED RADIATION THERAPY
AU2001249608A1 (en) * 2000-03-28 2001-10-08 Beth Israel Deaconess Medical Center Bladder cancer-specific peptides for diagnosis and therapy
NZ545176A (en) * 2001-01-29 2008-05-30 Biogen Idec Inc Modified antibodies reactive with CD20 and methods of use
AU2003259835A1 (en) * 2002-08-15 2004-03-03 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to trail receptors

Also Published As

Publication number Publication date
IL175674A0 (en) 2006-09-05
MXPA06006683A (en) 2006-08-11
CR8439A (en) 2006-12-07
CA2546057A1 (en) 2005-06-23
RU2006124510A (en) 2008-01-20
WO2005056058A2 (en) 2005-06-23
WO2005056058A3 (en) 2006-04-13
KR20060118542A (en) 2006-11-23
AU2004296621A1 (en) 2005-06-23
NO20063207L (en) 2006-07-10
CN101031319A (en) 2007-09-05
EP1691838A2 (en) 2006-08-23
JP2007528874A (en) 2007-10-18
BRPI0417517A (en) 2007-03-06

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