ECSP066306A - STABLE MODIFICATIONS OF TEGASEROD ACID MALEATE - Google Patents
STABLE MODIFICATIONS OF TEGASEROD ACID MALEATEInfo
- Publication number
- ECSP066306A ECSP066306A EC2006006306A ECSP066306A ECSP066306A EC SP066306 A ECSP066306 A EC SP066306A EC 2006006306 A EC2006006306 A EC 2006006306A EC SP066306 A ECSP066306 A EC SP066306A EC SP066306 A ECSP066306 A EC SP066306A
- Authority
- EC
- Ecuador
- Prior art keywords
- tegaserod
- acid maleate
- stable modifications
- stable
- modifications
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Plant Substances (AREA)
- Glass Compositions (AREA)
- Liquid Crystal Substances (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invención se refiere a formas cristalinas del maleato ácido de tegaserod; a su uso en composiciones farmacéuticas útiles en el tratamiento del síndrome de intestino irritable, de la enfermedad de reflujo gastroesofágico, de dispepsia funcional, de constipación crónica o de diarrea, y a su producción.The present invention relates to crystalline forms of tegaserod acid maleate; to its use in pharmaceutical compositions useful in the treatment of irritable bowel syndrome, gastroesophageal reflux disease, functional dyspepsia, chronic constipation or diarrhea, and its production.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US48963803P | 2003-07-24 | 2003-07-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP066306A true ECSP066306A (en) | 2006-07-28 |
Family
ID=34135099
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EC2006006306A ECSP066306A (en) | 2003-07-24 | 2006-01-24 | STABLE MODIFICATIONS OF TEGASEROD ACID MALEATE |
Country Status (24)
Country | Link |
---|---|
US (1) | US20070112056A1 (en) |
EP (2) | EP1880992A1 (en) |
JP (1) | JP2006528609A (en) |
KR (1) | KR20060040710A (en) |
CN (1) | CN1826318A (en) |
AR (1) | AR045081A1 (en) |
AU (1) | AU2004263285A1 (en) |
BR (1) | BRPI0412830A (en) |
CA (1) | CA2532351A1 (en) |
CO (1) | CO5680418A2 (en) |
EC (1) | ECSP066306A (en) |
IL (1) | IL172914A0 (en) |
IS (1) | IS8321A (en) |
MA (1) | MA27935A1 (en) |
MX (1) | MXPA06000917A (en) |
MY (1) | MY137386A (en) |
NO (1) | NO20060915L (en) |
NZ (1) | NZ544596A (en) |
PE (1) | PE20050253A1 (en) |
RU (1) | RU2349585C2 (en) |
SG (1) | SG144944A1 (en) |
TN (1) | TNSN06024A1 (en) |
TW (1) | TW200510302A (en) |
WO (1) | WO2005014544A1 (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006045120A2 (en) * | 2004-10-19 | 2006-04-27 | Teva Pharmaceutical Industries Ltd. | Purification of tegaserod maleate |
RU2007132704A (en) * | 2005-01-31 | 2009-03-10 | Новартис АГ (CH) | ORGANIC COMPOUNDS |
CZ298399B6 (en) * | 2005-05-02 | 2007-09-19 | Zentiva, A. S. | Process for preparing 2-[(5-methoxy-1 H-indol-3-yl) methylene]-N-pentylcarbazimidamide (tegaserod) |
WO2007002314A2 (en) * | 2005-06-22 | 2007-01-04 | Teva Pharmaceutical Industries Ltd. | Polymorphic forms of tegaserod maleate |
WO2007119109A2 (en) * | 2005-10-06 | 2007-10-25 | Medichem, S.A. | Processes for preparing tegaserod maleate and pharmaceutical compositions containing it |
GB0524668D0 (en) * | 2005-12-02 | 2006-01-11 | Novartis Ag | Organic compounds |
WO2007120924A1 (en) * | 2006-04-17 | 2007-10-25 | Teva Pharmaceutical Industries Ltd. | Preparation of tegaserod maleate free of iodide |
EP1956002A1 (en) * | 2007-02-07 | 2008-08-13 | Chemo Ibérica, S.A. | New tegaserod maleate polymorphs and process for their preparation |
EP2146958A1 (en) * | 2007-05-17 | 2010-01-27 | Generics Ýuk¨Limited | Process for the preparation of form a of tegaserod |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH01242588A (en) * | 1988-03-25 | 1989-09-27 | Chiba Gosei Kenkyusho:Kk | Crystal of 7-cyanomethylthioacetamide-7alpha-methoxy-3-(1-methyl-1h-tetrazol-5-yl)thiomethyl-3-cephem-4-carboxylic acid and production thereof |
HUT64023A (en) * | 1991-03-22 | 1993-11-29 | Sandoz Ag | Process for producing aminoguanidine derivatives and pharmaceutical compositions comprising such compounds |
JPH08291140A (en) * | 1995-04-20 | 1996-11-05 | Teikoku Chem Ind Corp Ltd | Easily absorbable crystal |
HU228179B1 (en) * | 1998-08-21 | 2013-01-28 | Novartis Ag | Pharmaceutical, oral compositions containing 5-ht4 agonists or antagonists as active agent |
EP1321142A1 (en) * | 2001-12-21 | 2003-06-25 | Novartis AG | Solid pharmaceutical composition for oral administration of Tegaserod |
CN1176077C (en) * | 2003-01-07 | 2004-11-17 | 江苏省药物研究所 | Tegaserod maleate-water crystal |
WO2004085393A1 (en) * | 2003-03-25 | 2004-10-07 | Hetero Drugs Limited | Novel crystalline forms of tegaserod maleate |
CA2550886A1 (en) * | 2003-12-16 | 2005-06-30 | Teva Pharmaceutical Industries Ltd. | Polymorphic forms of tegaserod base and salts thereof |
US20050272802A1 (en) * | 2004-04-22 | 2005-12-08 | Sundaram Venkataraman | Process for preparing form I of tegaserod maleate |
WO2007002314A2 (en) * | 2005-06-22 | 2007-01-04 | Teva Pharmaceutical Industries Ltd. | Polymorphic forms of tegaserod maleate |
-
2004
- 2004-07-22 PE PE2004000706A patent/PE20050253A1/en not_active Application Discontinuation
- 2004-07-22 TW TW093121920A patent/TW200510302A/en unknown
- 2004-07-22 AR ARP040102610A patent/AR045081A1/en not_active Application Discontinuation
- 2004-07-22 MY MYPI20042945A patent/MY137386A/en unknown
- 2004-07-23 EP EP07117155A patent/EP1880992A1/en not_active Withdrawn
- 2004-07-23 KR KR1020067001500A patent/KR20060040710A/en not_active Application Discontinuation
- 2004-07-23 RU RU2006105481/04A patent/RU2349585C2/en not_active IP Right Cessation
- 2004-07-23 CN CNA2004800213549A patent/CN1826318A/en active Pending
- 2004-07-23 BR BRPI0412830-3A patent/BRPI0412830A/en not_active IP Right Cessation
- 2004-07-23 NZ NZ544596A patent/NZ544596A/en unknown
- 2004-07-23 EP EP04763452A patent/EP1651601A1/en not_active Withdrawn
- 2004-07-23 WO PCT/EP2004/008281 patent/WO2005014544A1/en not_active Application Discontinuation
- 2004-07-23 CA CA002532351A patent/CA2532351A1/en not_active Abandoned
- 2004-07-23 AU AU2004263285A patent/AU2004263285A1/en not_active Abandoned
- 2004-07-23 US US10/565,454 patent/US20070112056A1/en not_active Abandoned
- 2004-07-23 SG SG200805476-9A patent/SG144944A1/en unknown
- 2004-07-23 JP JP2006520806A patent/JP2006528609A/en active Pending
- 2004-07-23 MX MXPA06000917A patent/MXPA06000917A/en unknown
-
2005
- 2005-12-29 IL IL172914A patent/IL172914A0/en unknown
-
2006
- 2006-01-23 TN TNP2006000024A patent/TNSN06024A1/en unknown
- 2006-01-24 EC EC2006006306A patent/ECSP066306A/en unknown
- 2006-01-27 MA MA28759A patent/MA27935A1/en unknown
- 2006-02-21 CO CO06016978A patent/CO5680418A2/en not_active Application Discontinuation
- 2006-02-22 IS IS8321A patent/IS8321A/en unknown
- 2006-02-24 NO NO20060915A patent/NO20060915L/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
MXPA06000917A (en) | 2006-03-30 |
TW200510302A (en) | 2005-03-16 |
CO5680418A2 (en) | 2006-09-29 |
EP1651601A1 (en) | 2006-05-03 |
RU2349585C2 (en) | 2009-03-20 |
NZ544596A (en) | 2009-01-31 |
MY137386A (en) | 2009-01-30 |
AR045081A1 (en) | 2005-10-12 |
KR20060040710A (en) | 2006-05-10 |
SG144944A1 (en) | 2008-08-28 |
CA2532351A1 (en) | 2005-02-17 |
CN1826318A (en) | 2006-08-30 |
JP2006528609A (en) | 2006-12-21 |
MA27935A1 (en) | 2006-06-01 |
US20070112056A1 (en) | 2007-05-17 |
EP1880992A1 (en) | 2008-01-23 |
WO2005014544A1 (en) | 2005-02-17 |
TNSN06024A1 (en) | 2007-10-03 |
IL172914A0 (en) | 2006-06-11 |
RU2006105481A (en) | 2007-09-20 |
AU2004263285A1 (en) | 2005-02-17 |
NO20060915L (en) | 2006-04-24 |
IS8321A (en) | 2006-02-22 |
BRPI0412830A (en) | 2006-09-26 |
PE20050253A1 (en) | 2005-06-03 |
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