ECSP066281A - PIRAZOLINAS AS PAR-1 ANTAGONISTS FOR THE TREATMENT OF CARDIOCIRCULATORY DISEASES - Google Patents

PIRAZOLINAS AS PAR-1 ANTAGONISTS FOR THE TREATMENT OF CARDIOCIRCULATORY DISEASES

Info

Publication number
ECSP066281A
ECSP066281A EC2006006281A ECSP066281A ECSP066281A EC SP066281 A ECSP066281 A EC SP066281A EC 2006006281 A EC2006006281 A EC 2006006281A EC SP066281 A ECSP066281 A EC SP066281A EC SP066281 A ECSP066281 A EC SP066281A
Authority
EC
Ecuador
Prior art keywords
treatment
diseases
pirazolinas
par
antagonists
Prior art date
Application number
EC2006006281A
Other languages
Spanish (es)
Inventor
Walter Huebsch
Nicole Diedrichs
Swen Allerheilingen
Dirk Brohm
Britta-Nicole Froehlen
Christoph Gerdes
Mark Jean Gnoth
Heike Heckroth
Elisabeth Perzborn
Elke Stahl
Verena Voehringer
Original Assignee
Bayer Healthcare Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Ag filed Critical Bayer Healthcare Ag
Publication of ECSP066281A publication Critical patent/ECSP066281A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La invención se refiere a pirazolinas de fórmula (I) en la que E representa metileno, NH, un átomo de oxígeno o un átomo de azufre, y R2 representa un grupo de fórmula (II), y a procedimientos para su preparación, así como su uso para la preparación de fármacos para el tratamiento y/o la profilaxis de enfermedades, especialmente de enfermedades cardiocirculatorias como, por ejemplo, enfermedades tromboembólicas. (II).The invention relates to pyrazolines of formula (I) in which E represents methylene, NH, an oxygen atom or a sulfur atom, and R2 represents a group of formula (II), and processes for their preparation, as well as their use for the preparation of drugs for the treatment and / or prophylaxis of diseases, especially of cardiocirculatory diseases such as thromboembolic diseases. (II).

EC2006006281A 2003-07-15 2006-01-12 PIRAZOLINAS AS PAR-1 ANTAGONISTS FOR THE TREATMENT OF CARDIOCIRCULATORY DISEASES ECSP066281A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10331951 2003-07-15
DE102004010545A DE102004010545A1 (en) 2003-07-15 2004-03-04 pyrazolines

Publications (1)

Publication Number Publication Date
ECSP066281A true ECSP066281A (en) 2006-07-28

Family

ID=34088638

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2006006281A ECSP066281A (en) 2003-07-15 2006-01-12 PIRAZOLINAS AS PAR-1 ANTAGONISTS FOR THE TREATMENT OF CARDIOCIRCULATORY DISEASES

Country Status (4)

Country Link
CN (1) CN1852710A (en)
DE (1) DE102004010545A1 (en)
EC (1) ECSP066281A (en)
IL (1) IL173136A0 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104086501B (en) * 2014-07-23 2016-02-17 张远强 A kind of PAR-1 antagonist, Preparation Method And The Use
CN111892585A (en) * 2020-08-05 2020-11-06 杭州维坦医药科技有限公司 N-formamido pyrazoline derivative as P2X3 receptor antagonist and application thereof

Also Published As

Publication number Publication date
IL173136A0 (en) 2006-06-11
CN1852710A (en) 2006-10-25
DE102004010545A1 (en) 2005-02-24

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