ECSP045479A - COMBINATIONS THAT INCLUDE EPOTILONES AND THEIR PHARMACEUTICAL USES - Google Patents

COMBINATIONS THAT INCLUDE EPOTILONES AND THEIR PHARMACEUTICAL USES

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Publication number
ECSP045479A
ECSP045479A ECSP045479A ECSP045479A EC SP045479 A ECSP045479 A EC SP045479A EC SP045479 A ECSP045479 A EC SP045479A EC SP045479 A ECSP045479 A EC SP045479A
Authority
EC
Ecuador
Prior art keywords
inhibitors
combination
treatment
topoisomerase
simultaneous
Prior art date
Application number
Other languages
Spanish (es)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of ECSP045479A publication Critical patent/ECSP045479A/en

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La invención se refiere a una combinación farmacéutica que comprende (a) un anticuerpo de HER-1 o HER-2, o (b) por lo menos un agente antineoplástico seleccionado del grupo que consiste de inhibidores de aromatasa, antiestrógenos, inhibidores de topoisomerasa I, inhibidores de topoisomerasa II, agentes activos de microtúbulo, inhibidores de cinasa C de proteína, compuestos anti-angiogénicos, agonistas de gonadorelina, anti-andrógenos, inhibidores de histona-desacetilasa e inhibidores de S-adenosil-metionina-descarboxilasa, y (c) un derivado de epotilona de la fórmula (I), y opcionalmente por lo menos un vehículo farmacéuticamente aceptable para uso simultáneo, separado o secuencial, en particular, para el tratamiento de una enfermedad proliferativa, especialmente una enfermedad de tumor sólido; una composición farmacéutica que comprende dicha combinación; el uso de dicha combinación para la preparación de un medicamento para el tratamiento de una enfermedad proliferativa; un paquete o producto comercial que comprende dicha combinación como una preparación combinada para uso simultáneo, separado o secuencial; y a un método para el tratamiento de un animal de sangre caliente, especialmente un ser humano.The invention relates to a pharmaceutical combination comprising (a) an HER-1 or HER-2 antibody, or (b) at least one antineoplastic agent selected from the group consisting of aromatase inhibitors, antiestrogens, topoisomerase I inhibitors , topoisomerase II inhibitors, active microtubule agents, protein kinase C inhibitors, anti-angiogenic compounds, gonadorelin agonists, anti-androgens, histone deacetylase inhibitors and S-adenosyl methionine decarboxylase inhibitors, and (c ) an epothilone derivative of the formula (I), and optionally at least one pharmaceutically acceptable carrier for simultaneous, separate or sequential use, in particular, for the treatment of a proliferative disease, especially a solid tumor disease; a pharmaceutical composition comprising said combination; the use of said combination for the preparation of a medicament for the treatment of a proliferative disease; a commercial package or product comprising said combination as a combined preparation for simultaneous, separate or sequential use; and to a method for the treatment of a warm-blooded animal, especially a human being.

ECSP045479 2002-06-10 2004-12-08 COMBINATIONS THAT INCLUDE EPOTILONES AND THEIR PHARMACEUTICAL USES ECSP045479A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US38702502P 2002-06-10 2002-06-10

Publications (1)

Publication Number Publication Date
ECSP045479A true ECSP045479A (en) 2005-01-28

Family

ID=35161211

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP045479 ECSP045479A (en) 2002-06-10 2004-12-08 COMBINATIONS THAT INCLUDE EPOTILONES AND THEIR PHARMACEUTICAL USES

Country Status (1)

Country Link
EC (1) ECSP045479A (en)

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