ECSP045455A - N-ACILAMINOBENCENO DERIVATIVES AS SELECTIVE INHIBITORS OF MONOAMINO OXIDASA B - Google Patents
N-ACILAMINOBENCENO DERIVATIVES AS SELECTIVE INHIBITORS OF MONOAMINO OXIDASA BInfo
- Publication number
- ECSP045455A ECSP045455A ECSP045455A ECSP045455A EC SP045455 A ECSP045455 A EC SP045455A EC SP045455 A ECSP045455 A EC SP045455A EC SP045455 A ECSP045455 A EC SP045455A
- Authority
- EC
- Ecuador
- Prior art keywords
- carbon atoms
- alkyl
- hydrogen
- alkoxy
- halogen
- Prior art date
Links
Abstract
Esta invención se refiere a derivados N-acilamino arilo de fórmula general en donde R1 es halógeno, -alquilo de 1 a 6 átomos de carbono, ciano, alcoxilo de 1 a 6 átomos de carbono ó halógeno-alcoxilo de 1 a 6 átomos de carbono; R21,R22,R23 y R24 independientemente entre sí se seleccionan del grupo formado por hidrógeno, alquilo de 1 a 6 átomos de carbono, halógeno, -alquilo de 1 a 6 átomos de carbono, hidroxilo, alcoxilo de 1 a 6 átomos de carbono ó -CHO;R3 es hidrógeno o alquilo de 1 a 3 átomos de carbono;R4, R5 independientemente entre sí, se seleccionan del grupo formado por hidrógeno, alquilo de 1 a 6 átomos de carbono, alcoxilo de 1 a 6 átomos de carbono ó -COO(alquilo de 1 a 6 átomos de carbono); ó R4 y R5 forman juntamente con el átomo de C al cual están unidos un anillo cicloalquilo de 3 a 7 átomos de carbono;R6 es -CO-NR7R8; -COO(alquilo de 1 a 6 átomos de carbono), -CN, -NR2 ó -NHC(O)R;R7 y R8 independientemente entre sí, se seleccionan del grupo formado por hidrógeno, alquilo de 1 a 6 átomos de carbono, NH2 ó hidroxilo;R es hidrógeno o alquilo de 1 a 6 átomos de carbono;n es 0, 1, 2 ó 3.X es -CHRO, -OCHR-, -CH2S-, -SCH2-, -CH2CH2-, -CH=CH- ó -CºC-; y a las sales de adición ácida farmacéuticamente activas de los mismos. Se ha descubierto que los compuestos de fórmula general I son inhibidores selectivos de la monoamino oxidasa, y son por lo tanto de utilidad en el tratamiento de enfermedades mediadas por los inhibidores de la monoamino oxidasa B, por ejemplo, para el tratamiento de la enfermedad de Alzheimer o la demencia senil.This invention relates to N-acylamino aryl derivatives of the general formula wherein R 1 is halogen, -alkyl of 1 to 6 carbon atoms, cyano, alkoxy of 1 to 6 carbon atoms or halogen-alkoxy of 1 to 6 carbon atoms ; R21, R22, R23 and R24 independently from each other are selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms, halogen, -alkyl of 1 to 6 carbon atoms, hydroxyl, alkoxy of 1 to 6 carbon atoms or -CHO; R3 is hydrogen or alkyl of 1 to 3 carbon atoms; R4, R5 independently of each other, are selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms or - COO (alkyl of 1 to 6 carbon atoms); or R4 and R5 together with the C atom to which a cycloalkyl ring of 3 to 7 carbon atoms is attached: R6 is -CO-NR7R8; -COO (alkyl of 1 to 6 carbon atoms), -CN, -NR2 or -NHC (O) R; R7 and R8 independently of each other, are selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms, NH2 or hydroxyl; R is hydrogen or alkyl of 1 to 6 carbon atoms; n is 0, 1, 2 or 3.X is -CHRO, -OCHR-, -CH2S-, -SCH2-, -CH2CH2-, -CH = CH- or -C ° C; and to the pharmaceutically active acid addition salts thereof. It has been found that the compounds of general formula I are selective inhibitors of monoamine oxidase, and are therefore useful in the treatment of diseases mediated by monoamine oxidase B inhibitors, for example, for the treatment of the disease of Alzheimer's or senile dementia.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP045455 ECSP045455A (en) | 2004-11-26 | 2004-11-26 | N-ACILAMINOBENCENO DERIVATIVES AS SELECTIVE INHIBITORS OF MONOAMINO OXIDASA B |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP045455 ECSP045455A (en) | 2004-11-26 | 2004-11-26 | N-ACILAMINOBENCENO DERIVATIVES AS SELECTIVE INHIBITORS OF MONOAMINO OXIDASA B |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP045455A true ECSP045455A (en) | 2005-01-28 |
Family
ID=40419316
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP045455 ECSP045455A (en) | 2004-11-26 | 2004-11-26 | N-ACILAMINOBENCENO DERIVATIVES AS SELECTIVE INHIBITORS OF MONOAMINO OXIDASA B |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP045455A (en) |
-
2004
- 2004-11-26 EC ECSP045455 patent/ECSP045455A/en unknown
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