ECSP034841A - Derivados de dipeptido que tienen un grupo 2-tioacilo n-terminal como inhibidores de vasopeptidasa - Google Patents
Derivados de dipeptido que tienen un grupo 2-tioacilo n-terminal como inhibidores de vasopeptidasaInfo
- Publication number
- ECSP034841A ECSP034841A ECSP034841A ECSP034841A EC SP034841 A ECSP034841 A EC SP034841A EC SP034841 A ECSP034841 A EC SP034841A EC SP034841 A ECSP034841 A EC SP034841A
- Authority
- EC
- Ecuador
- Prior art keywords
- terminal
- inhibitors
- dipeptide derivatives
- vasopeptidase inhibitors
- coor2
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 3
- 108010016626 Dipeptides Proteins 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- UUUHXMGGBIUAPW-UHFFFAOYSA-N 1-[1-[2-[[5-amino-2-[[1-[5-(diaminomethylideneamino)-2-[[1-[3-(1h-indol-3-yl)-2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbon Chemical compound C1CCC(C(=O)N2C(CCC2)C(O)=O)N1C(=O)C(C(C)CC)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C1CCCN1C(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C1CCC(=O)N1 UUUHXMGGBIUAPW-UHFFFAOYSA-N 0.000 abstract 1
- 102000048186 Endothelin-converting enzyme 1 Human genes 0.000 abstract 1
- 108030001679 Endothelin-converting enzyme 1 Proteins 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 102000003729 Neprilysin Human genes 0.000 abstract 1
- 108090000028 Neprilysin Proteins 0.000 abstract 1
- 102000004270 Peptidyl-Dipeptidase A Human genes 0.000 abstract 1
- 108090000882 Peptidyl-Dipeptidase A Proteins 0.000 abstract 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- -1 methoxyacetyl Chemical group 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
en donde R, R1, COOR2, R3-R7, alk, y X tienen los significados como se definen, siendo éstos útiles como inhibidores dobles de la enzima convertidora de angiotensina y de la endopeptidasa neutra, así como inhibidores de la enzima convertidora de endotelina. En una modalidad preferida R y R5 representan hidrógeno; R1 representa bencilo; R3 representa hidrógeno, acetilo o metoxiacetilo; R4 representa isopropilo o butilo terciario; R6 y R7 representan metilo; X representa -O-; alk representa metileno; y COOR2 representa carboxilo o etoxicarbonilo
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29108801P | 2001-05-15 | 2001-05-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP034841A true ECSP034841A (es) | 2003-12-24 |
Family
ID=34078854
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP034841 ECSP034841A (es) | 2001-05-15 | 2003-11-11 | Derivados de dipeptido que tienen un grupo 2-tioacilo n-terminal como inhibidores de vasopeptidasa |
Country Status (2)
| Country | Link |
|---|---|
| EC (1) | ECSP034841A (es) |
| ZA (1) | ZA200308590B (es) |
-
2003
- 2003-11-04 ZA ZA200308590A patent/ZA200308590B/en unknown
- 2003-11-11 EC ECSP034841 patent/ECSP034841A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200308590B (en) | 2004-05-21 |
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