ECSP034751A - DERIVATIVES OF PIPERIDINE ACILATED AS AGONISTS OF THE RECEIVER MELANOCORTINA-4 - Google Patents
DERIVATIVES OF PIPERIDINE ACILATED AS AGONISTS OF THE RECEIVER MELANOCORTINA-4Info
- Publication number
- ECSP034751A ECSP034751A ECSP034751A ECSP034751A EC SP034751 A ECSP034751 A EC SP034751A EC SP034751 A ECSP034751 A EC SP034751A EC SP034751 A ECSP034751 A EC SP034751A
- Authority
- EC
- Ecuador
- Prior art keywords
- piperidine
- derivatives
- agonists
- melanocortina
- acilated
- Prior art date
Links
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical class C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title abstract 3
- 239000000556 agonist Substances 0.000 title 1
- 208000010228 Erectile Dysfunction Diseases 0.000 abstract 1
- 206010057671 Female sexual dysfunction Diseases 0.000 abstract 1
- 206010057672 Male sexual dysfunction Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 102000008316 Type 4 Melanocortin Receptor Human genes 0.000 abstract 1
- 108010021436 Type 4 Melanocortin Receptor Proteins 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 201000001881 impotence Diseases 0.000 abstract 1
- 239000000336 melanocortin receptor agonist Substances 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 150000003053 piperidines Chemical class 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 239000000018 receptor agonist Substances 0.000 abstract 1
- 229940044601 receptor agonist Drugs 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invención se refiere a piperidinas N-asiladas 4 sustituidas novedosas de fórmula estructural I: Estos derivados de piperidina asilada son efectivos como agonistas del receptor de melanocortina y son particularmente efectivos como agonistas selectivos del receptor de melanocortina-4 (MC-4R):Son por lo tanto útiles para el tratamiento y/o prevención de trastornos que responden a la activación de MC-$R, tales como obesidad, diabetes así como disfunción sexual masculina y femenina, en particular la disfunción eréctil masculina.The present invention relates to novel substituted N-asylated piperidines 4 of structural formula I: These derivatives of asylated piperidine are effective as melanocortin receptor agonists and are particularly effective as selective melanocortin-4 receptor agonists (MC-4R): They are therefore useful for the treatment and / or prevention of disorders that respond to the activation of MC-R, such as obesity, diabetes as well as male and female sexual dysfunction, in particular male erectile dysfunction.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27225801P | 2001-02-28 | 2001-02-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP034751A true ECSP034751A (en) | 2003-10-28 |
Family
ID=34078835
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP034751 ECSP034751A (en) | 2001-02-28 | 2003-08-27 | DERIVATIVES OF PIPERIDINE ACILATED AS AGONISTS OF THE RECEIVER MELANOCORTINA-4 |
Country Status (2)
| Country | Link |
|---|---|
| EC (1) | ECSP034751A (en) |
| ZA (1) | ZA200306160B (en) |
-
2003
- 2003-08-08 ZA ZA200306160A patent/ZA200306160B/en unknown
- 2003-08-27 EC ECSP034751 patent/ECSP034751A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200306160B (en) | 2004-07-21 |
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