ECSP024408A - PIPERIDINE COMPOUNDS FOR USE AS CCR-3 INHIBITORS - Google Patents

PIPERIDINE COMPOUNDS FOR USE AS CCR-3 INHIBITORS

Info

Publication number
ECSP024408A
ECSP024408A ECSP024408A ECSP024408A EC SP024408 A ECSP024408 A EC SP024408A EC SP024408 A ECSP024408 A EC SP024408A EC SP024408 A ECSP024408 A EC SP024408A
Authority
EC
Ecuador
Prior art keywords
carbon atoms
alkyl
hydrogen
halogen
phenyl
Prior art date
Application number
Other languages
Spanish (es)
Inventor
Gurdip Bhalay
Thomas Storz
Trevor John Howe
Darren Mark Grand
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of ECSP024408A publication Critical patent/ECSP024408A/en

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Compuesto de la fórmula (gráfico) en forma libre o de sal, en donde: Ar1 es fenilo sustituido por uno o más átomos de halógeno, ar2 es fenilo o naftilo que está instituido o sustituido por uno o mas sustituyentes seleccionados a partir del halógeno, ciano, hidroxilo, nitro, alquilo de 1 a 8 átomos de carbono, alcoxilo de 1 a 8 átomos de carbono, o alcoxicarbonilo de 1 a 8 átomos de carbono, R1 es hidrógeno o alquilo hidrógeno o alquilo de 1 a 8 átomos de carbono opcionalmente sustituido por hidroxilo, alcixilo de 1 a 8 átomos de carbono, aciloxilo, -N(R2)R3, halógeno, carboxilo, alcoxicarbonilo de 1 a 8 átomos de carbono, -CON(R4)R5 o por un grupo orgánico cíclico monovalente, R2 y R3 son cada uno independientemente hidrógeno o alquilo de 1a 8 átomos de carbono, o R2 es hidrógeno y R3es acilo o -SO2 R6, o R2 y R3, junto con el átomo de nitrógeno con el que están unidos, denotan un grupo heterocíclico de 5 o 6 miembros, R4 y R5 son cada uno independientemente hidrógeno o alquilo de 1 a 8 átomos de carbono, o R4 yR5 , junto con el átomo de nitrógeno con el que están unidos denotan un grupo heterocíclico de 5 o 6 miembros, R4 y R5 son cada uno independientemente hidrogeno o alquilo de 1 a 8 átomos de carbono y n es 1, 2, 3, o 4, con la condición de que cuando Ar1 es p-clorofenilo y R1 es hidrógeno, Ar2 no sea fenilo o p-nitrofenilo. Los compuestos son útiles como productos farmacéuticos.Compound of the formula (graph) in free or salt form, wherein: Ar1 is phenyl substituted by one or more halogen atoms, ar2 is phenyl or naphthyl which is instituted or substituted by one or more substituents selected from the halogen, cyano, hydroxyl, nitro, alkyl of 1 to 8 carbon atoms, alkoxy of 1 to 8 carbon atoms, or alkoxycarbonyl of 1 to 8 carbon atoms, R1 is hydrogen or hydrogen alkyl or alkyl of 1 to 8 carbon atoms optionally substituted by hydroxyl, alkyxyl of 1 to 8 carbon atoms, acyloxy, -N (R2) R3, halogen, carboxyl, alkoxycarbonyl of 1 to 8 carbon atoms, -CON (R4) R5 or by a monovalent cyclic organic group, R2 and R3 are each independently hydrogen or alkyl of 1-8 carbon atoms, or R2 is hydrogen and R3 is acyl or -SO2 R6, or R2 and R3, together with the nitrogen atom with which they are attached, denote a heterocyclic group of 5 or 6 members, R4 and R5 are each independently hi halogen or alkyl of 1 to 8 carbon atoms, or R4 and R5, together with the nitrogen atom with which they are attached denote a 5- or 6-membered heterocyclic group, R4 and R5 are each independently hydrogen or alkyl of 1 to 8 carbon atoms and n is 1, 2, 3, or 4, with the proviso that when Ar1 is p-chlorophenyl and R1 is hydrogen, Ar2 is not phenyl or p-nitrophenyl. The compounds are useful as pharmaceuticals.

ECSP024408 2000-07-12 2002-12-27 PIPERIDINE COMPOUNDS FOR USE AS CCR-3 INHIBITORS ECSP024408A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB0017174A GB0017174D0 (en) 2000-07-12 2000-07-12 Organic compounds

Publications (1)

Publication Number Publication Date
ECSP024408A true ECSP024408A (en) 2003-02-06

Family

ID=9895565

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP024408 ECSP024408A (en) 2000-07-12 2002-12-27 PIPERIDINE COMPOUNDS FOR USE AS CCR-3 INHIBITORS

Country Status (4)

Country Link
EC (1) ECSP024408A (en)
GB (1) GB0017174D0 (en)
RU (1) RU2278856C2 (en)
ZA (1) ZA200300281B (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE910818A1 (en) * 1990-08-09 1992-02-12 Sankyo Co (benzhydryloxyethylpiperidyl)aliphatic acid derivatives and¹their use in the treatment of allergies and asthma
WO1999004794A1 (en) * 1997-07-25 1999-02-04 Merck & Co., Inc. Cyclic amine modulators of chemokine receptor activity
CN1163484C (en) * 1998-11-17 2004-08-25 霍夫曼-拉罗奇有限公司 4-Aroyl-piperidine-CCR-3 receptor antagonist Ⅲ

Also Published As

Publication number Publication date
RU2278856C2 (en) 2006-06-27
ZA200300281B (en) 2004-04-08
GB0017174D0 (en) 2000-08-30

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