ECSP003845A - NITRILE DERIVATIVES AS CATEPSIN K INHIBITORS - Google Patents
NITRILE DERIVATIVES AS CATEPSIN K INHIBITORSInfo
- Publication number
- ECSP003845A ECSP003845A ECSP003845A ECSP003845A EC SP003845 A ECSP003845 A EC SP003845A EC SP003845 A ECSP003845 A EC SP003845A EC SP003845 A ECSP003845 A EC SP003845A
- Authority
- EC
- Ecuador
- Prior art keywords
- diseases
- compounds
- pharmaceutically acceptable
- angina pectoris
- catepsin
- Prior art date
Links
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención se refiere a compuestos de fórmula (I) En donde R1 a R7 e Y son tal como se definen en la descripción y las reivindicaciones, y las sales farmacéuticamente aceptables y/o ésteres farmacéuticamente aceptables de los mismos. Los compuestos son útiles para el tratamiento de enfermedades que estén asociadas con las proteasas cisteínicas, tales como la osteoporósis, osteoartritis, artritis reumatoide, metástasis tumoral, glomerulonefritis, arterosclerosis, infarto de miocardio, angina de pecho, angina de pecho inestable, embolia, rotura de placa, ataques isquémicos transitorios, amaurosis fugax, enfermedad oclusiva de las arterias periféricas, restenosis después de angioplastia y colocación de stents, formación de aneurismo aórtico, inflamación, enfermedades autoinmunes, malaria, citopatía del tejido del fondo ocular, y enfermedades respiratorias.The present invention relates to compounds of formula (I) wherein R1 to R7 and Y are as defined in the description and claims, and pharmaceutically acceptable salts and / or pharmaceutically acceptable esters thereof. The compounds are useful for the treatment of diseases that are associated with cysteine proteases, such as osteoporosis, osteoarthritis, rheumatoid arthritis, tumor metastasis, glomerulonephritis, atherosclerosis, myocardial infarction, angina pectoris, unstable angina pectoris, embolism, rupture of plaque, transient ischemic attacks, fugax amaurosis, peripheral artery occlusive disease, restenosis after angioplasty and stenting, formation of aortic aneurism, inflammation, autoimmune diseases, malaria, ocular fundus cytopathy, and respiratory diseases.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP003845 ECSP003845A (en) | 2000-12-21 | 2000-12-21 | NITRILE DERIVATIVES AS CATEPSIN K INHIBITORS |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP003845 ECSP003845A (en) | 2000-12-21 | 2000-12-21 | NITRILE DERIVATIVES AS CATEPSIN K INHIBITORS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP003845A true ECSP003845A (en) | 2001-07-27 |
Family
ID=42041395
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP003845 ECSP003845A (en) | 2000-12-21 | 2000-12-21 | NITRILE DERIVATIVES AS CATEPSIN K INHIBITORS |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP003845A (en) |
-
2000
- 2000-12-21 EC ECSP003845 patent/ECSP003845A/en unknown
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