ECSP003720A - MODIFIED AND PEPTIDOMIMETIC PEPTIDES FOR USE IN IMMUNOTHERAPY - Google Patents

MODIFIED AND PEPTIDOMIMETIC PEPTIDES FOR USE IN IMMUNOTHERAPY

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Publication number
ECSP003720A
ECSP003720A ECSP003720A ECSP003720A EC SP003720 A ECSP003720 A EC SP003720A EC SP003720 A ECSP003720 A EC SP003720A EC SP003720 A ECSP003720 A EC SP003720A
Authority
EC
Ecuador
Prior art keywords
amino acids
substitution
formula
ser
modified
Prior art date
Application number
Other languages
Spanish (es)
Inventor
Cornelis Marius Timmers
Anna Maria Helena Boots
Catherina Joanna Staveren
Philipus Johannes Marie Galen
Ronald Marcelius Knegtel
Andreas Martinus Maria Miltenburg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to ECSP003720 priority Critical patent/ECSP003720A/en
Publication of ECSP003720A publication Critical patent/ECSP003720A/en

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Abstract

La invención se refiere a un péptido modificado derivado de H-Arg-Ser-Phe-Thr-Leu-Ala-Ser-Ser-Glu-Thr-Gly-Val-Gly-OH (formula I) que tiene la fórmula general Q-A1-A2-A3-A4-A5-A6-A7-A8-A9-A10-A11-A12-A13-Z (formula II). En la Fórmula general II, A1 a A13 corresponden a los amino ácidos de la fórmula I, Q corresponde a H y Z corresponde a OH. Las modificacione de acuerdo con la presente invención se seleccionan de uno o más de los grupos a, b o c, consistentes en: sustitución de 1-6, de preferencia 1-4 amino ácidos en A1 a A13 por amino ácidos no naturales o b amino ácidos., sustitución de uno o más enlaces amida por enlaces amida reducidos o isoesteres de etileno, sustitución en Q y/o Z y, opcionalmente, sustitución por amino ácidos naturales, hasta un total de 6 modificaciones. Los péptidos pueden usarse para la inducción de tolerancia en pacientes que sufren de enfermedades autoinmunes.The invention relates to a modified peptide derived from H-Arg-Ser-Phe-Thr-Leu-Ala-Ser-Ser-Glu-Thr-Gly-Val-Gly-OH (formula I) having the general formula Q- A1-A2-A3-A4-A5-A6-A7-A8-A9-A10-A11-A12-A13-Z (formula II). In the general Formula II, A1 to A13 correspond to the amino acids of the formula I, Q corresponds to H and Z corresponds to OH. Modifications according to the present invention are selected from one or more of the groups a, boc, consisting of: substitution of 1-6, preferably 1-4 amino acids in A1 to A13 by non-natural amino acids or amino acids. , substitution of one or more amide bonds by reduced amide bonds or isoesters of ethylene, substitution at Q and / or Z and, optionally, substitution by natural amino acids, up to a total of 6 modifications. Peptides can be used for tolerance induction in patients suffering from autoimmune diseases.

ECSP003720 2000-10-18 2000-10-18 MODIFIED AND PEPTIDOMIMETIC PEPTIDES FOR USE IN IMMUNOTHERAPY ECSP003720A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ECSP003720 ECSP003720A (en) 2000-10-18 2000-10-18 MODIFIED AND PEPTIDOMIMETIC PEPTIDES FOR USE IN IMMUNOTHERAPY

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ECSP003720 ECSP003720A (en) 2000-10-18 2000-10-18 MODIFIED AND PEPTIDOMIMETIC PEPTIDES FOR USE IN IMMUNOTHERAPY

Publications (1)

Publication Number Publication Date
ECSP003720A true ECSP003720A (en) 2001-05-23

Family

ID=42041300

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP003720 ECSP003720A (en) 2000-10-18 2000-10-18 MODIFIED AND PEPTIDOMIMETIC PEPTIDES FOR USE IN IMMUNOTHERAPY

Country Status (1)

Country Link
EC (1) ECSP003720A (en)

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