ECSP003720A - MODIFIED AND PEPTIDOMIMETIC PEPTIDES FOR USE IN IMMUNOTHERAPY - Google Patents
MODIFIED AND PEPTIDOMIMETIC PEPTIDES FOR USE IN IMMUNOTHERAPYInfo
- Publication number
- ECSP003720A ECSP003720A ECSP003720A ECSP003720A EC SP003720 A ECSP003720 A EC SP003720A EC SP003720 A ECSP003720 A EC SP003720A EC SP003720 A ECSP003720 A EC SP003720A
- Authority
- EC
- Ecuador
- Prior art keywords
- amino acids
- substitution
- formula
- ser
- modified
- Prior art date
Links
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- Peptides Or Proteins (AREA)
Abstract
La invención se refiere a un péptido modificado derivado de H-Arg-Ser-Phe-Thr-Leu-Ala-Ser-Ser-Glu-Thr-Gly-Val-Gly-OH (formula I) que tiene la fórmula general Q-A1-A2-A3-A4-A5-A6-A7-A8-A9-A10-A11-A12-A13-Z (formula II). En la Fórmula general II, A1 a A13 corresponden a los amino ácidos de la fórmula I, Q corresponde a H y Z corresponde a OH. Las modificacione de acuerdo con la presente invención se seleccionan de uno o más de los grupos a, b o c, consistentes en: sustitución de 1-6, de preferencia 1-4 amino ácidos en A1 a A13 por amino ácidos no naturales o b amino ácidos., sustitución de uno o más enlaces amida por enlaces amida reducidos o isoesteres de etileno, sustitución en Q y/o Z y, opcionalmente, sustitución por amino ácidos naturales, hasta un total de 6 modificaciones. Los péptidos pueden usarse para la inducción de tolerancia en pacientes que sufren de enfermedades autoinmunes.The invention relates to a modified peptide derived from H-Arg-Ser-Phe-Thr-Leu-Ala-Ser-Ser-Glu-Thr-Gly-Val-Gly-OH (formula I) having the general formula Q- A1-A2-A3-A4-A5-A6-A7-A8-A9-A10-A11-A12-A13-Z (formula II). In the general Formula II, A1 to A13 correspond to the amino acids of the formula I, Q corresponds to H and Z corresponds to OH. Modifications according to the present invention are selected from one or more of the groups a, boc, consisting of: substitution of 1-6, preferably 1-4 amino acids in A1 to A13 by non-natural amino acids or amino acids. , substitution of one or more amide bonds by reduced amide bonds or isoesters of ethylene, substitution at Q and / or Z and, optionally, substitution by natural amino acids, up to a total of 6 modifications. Peptides can be used for tolerance induction in patients suffering from autoimmune diseases.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ECSP003720 ECSP003720A (en) | 2000-10-18 | 2000-10-18 | MODIFIED AND PEPTIDOMIMETIC PEPTIDES FOR USE IN IMMUNOTHERAPY |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ECSP003720 ECSP003720A (en) | 2000-10-18 | 2000-10-18 | MODIFIED AND PEPTIDOMIMETIC PEPTIDES FOR USE IN IMMUNOTHERAPY |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP003720A true ECSP003720A (en) | 2001-05-23 |
Family
ID=42041300
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ECSP003720 ECSP003720A (en) | 2000-10-18 | 2000-10-18 | MODIFIED AND PEPTIDOMIMETIC PEPTIDES FOR USE IN IMMUNOTHERAPY |
Country Status (1)
Country | Link |
---|---|
EC (1) | ECSP003720A (en) |
-
2000
- 2000-10-18 EC ECSP003720 patent/ECSP003720A/en unknown
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