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Derivados de amida de compuestos de piperidina 1,4-disustituida de la fórmula (gráfico), o una sal, éster o solvato farmacéuticamente aceptable del mismo, en donde Q y Q1 son cada uno -CH=, o uno de Q y Q1 es -CH= y el otro es N=; X es -CH2- o (gráfico), Y y Z son -C(R5)=, o uno de Y y Z es -C(R5)=y el otro es -N=; R1 es de 1 a 3 sustituyentes seleccionados entre H, halógeno y alcoxi; R2 y R5 son de 1 a 3 sustituyentes seleccionados entre H, halógeno, alquilo y alcoxi; y R3 y R4 son H o alquilo (C1-C6) son antagonistas muscarínicos útiles para el tratamiento de trastornos cognitivos como ser la enfermedad de Alzheimer. También se describen composiciones farmacéuticas y métodos de preparación.Amide derivatives of 1,4-disubstituted piperidine compounds of the formula (graph), or a pharmaceutically acceptable salt, ester or solvate thereof, wherein Q and Q1 are each -CH =, or one of Q and Q1 is -CH = and the other is N =; X is -CH2- or (graph), Y and Z are -C (R5) =, or one of Y and Z is -C (R5) = and the other is -N =; R1 is 1 to 3 substituents selected from H, halogen and alkoxy; R2 and R5 are 1 to 3 substituents selected from H, halogen, alkyl and alkoxy; and R3 and R4 are H or (C1-C6) alkyl are muscarinic antagonists useful for the treatment of cognitive disorders such as Alzheimer's disease. Pharmaceutical compositions and preparation methods are also described.
DERIVATIVES OF N- (QUINOLIN-5L) ALQUILAMIDA-REPLACED; N-ALQUILQUINOLIN-5-CARBOXAMIDA-REPLACED; N-ALQUILISOQUINOLIN-5-CARBOXAMIDA-SUBSTITUTED; N- (ISOQUINOLIN-5-YL) ALQUILAMIDA-REPLACED AND PROCESSES FOR PREPARATION
USE OF 3-AMINO-4-ARIL-MALEIMIDAS DERIVATIVE COMPOUNDS FOR THE PREPARATION OF MEDICINES FOR CONDITIONS ASSOCIATED WITH A NEED FOR INHIBITION OF LAGSK-3, SUCH COMPOUNDS, PROCEDURE FOR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT UNDERSTAND THEM
DERIVATIVES OF OXAZOL, PROCESS FOR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT INCLUDE THEM, AND THE USE OF SUCH COMPOUNDS IN THE PREPARATION OF MEDICINES
DERIVED FROM ADAMANTANO, ITS USE IN THE MANUFACTURE OF A MEDICINAL PRODUCT FOR USE IN THERAPY, PHARMACEUTICAL COMPOSITION, PROCESS FOR THE PREPARATION OF SUCH COMPOUND AND SUCH COMPOSITION AND INTERMEDIATE COMPOUNDS
COMPOUNDS DERIVED FROM PHENYL-PIPERAZINE, PHENYL-PIPERIDINE AND PHENYL-TETRAHIDROPIRIDINE AS INHIBITORS OF THE REABSORTION OF SEROTONIN, A PHARMACEUTICAL COMPOSITION AND USE OF THE SAME FOR THE PREPARATION OF MEDICINES