ECSP003463A - USEFUL PIPERIDINE DERIVATIVES AS CCR5 ANTAGONISTS - Google Patents
USEFUL PIPERIDINE DERIVATIVES AS CCR5 ANTAGONISTSInfo
- Publication number
- ECSP003463A ECSP003463A ECSP003463A ECSP003463A EC SP003463 A ECSP003463 A EC SP003463A EC SP003463 A ECSP003463 A EC SP003463A EC SP003463 A ECSP003463 A EC SP003463A
- Authority
- EC
- Ecuador
- Prior art keywords
- alkyl
- ch2c
- naphthyl
- optionally substituted
- heteroaryl
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
El uso de antagonistas CCR5 que tienen la fórmula (gráfico), o de una sal farmacéuticamente aceptable de los mismos, donde X es -C(R13)2-, -C(R13)(R19)-, -C(O)-, -O-, -NH-, -N(alquilo)-, (FÓRMULA) R es fenilo, piridilo, tiofenilo, o naftilo opcionalmente sustituido; R1 es H, alquilo o alquenilo; R2 es fenilo, fenilalquilo, heteroarilo o heteroarilalquilo, naftilo, fluorenilo o difenilmetilo opcionalmente sustituido; R3 es fenilo, heteroarilo o naftilo opcionalmente sustituido; R4 es H, alquilo, fluor-alquilo, ciclopropilmetilo, -CH2CH2OH, -CH2CH2-O-alquilo, -CH2C(O)-O-alquilo, -CH2C(O)-NH2 -CH2C(O)-NH alquilo o -CH2C(O)-N(alquilo)2; R19 es fenilo, heteroarilo, o naftilo, cicloalquilo, cicloalquilalquilo o alcoxialquilo opcionalmente sustituido; y R5, R13, R14, R15 y R16 son hidrógeno o alquilo para el tratamiento de HIV, rechazo a los transplantes de órganos sólidos, enfermedad de injerto versus huésped, artritis, artritis reumatoide, enfermedad inflamatoria del intestino, dermatitis atópica psoriasis, asma, alergias o esclerosis múltiple, asi como también nuevos compuestos, composiciones farmacéuticas que los comprenden, y la combinación de antagonistas CCR5 de la invención en combinación con agentes antivirales que son útiles en el tratamiento de HIV o agentes que son útiles en el tratamiento de enfermedades inflamatorias.The use of CCR5 antagonists having the formula (graph), or a pharmaceutically acceptable salt thereof, where X is -C (R13) 2-, -C (R13) (R19) -, -C (O) - , -O-, -NH-, -N (alkyl) -, (FORMULA) R is optionally substituted phenyl, pyridyl, thiophenyl, or naphthyl; R1 is H, alkyl or alkenyl; R2 is optionally substituted phenyl, phenylalkyl, heteroaryl or heteroarylalkyl, naphthyl, fluorenyl or diphenylmethyl; R3 is optionally substituted phenyl, heteroaryl, or naphthyl; R4 is H, alkyl, fluoroalkyl, cyclopropylmethyl, -CH2CH2OH, -CH2CH2-O-alkyl, -CH2C (O) -O-alkyl, -CH2C (O) -NH2 -CH2C (O) -NH alkyl or -CH2C (O) -N (alkyl) 2; R19 is phenyl, heteroaryl, or naphthyl, cycloalkyl, cycloalkylalkyl or optionally substituted alkoxyalkyl; and R5, R13, R14, R15 and R16 are hydrogen or alkyl for the treatment of HIV, rejection of solid organ transplants, graft versus host disease, arthritis, rheumatoid arthritis, inflammatory bowel disease, atopic dermatitis, psoriasis, asthma, allergies or multiple sclerosis, as well as new compounds, pharmaceutical compositions comprising them, and the combination of CCR5 antagonists of the invention in combination with antiviral agents that are useful in the treatment of HIV or agents that are useful in the treatment of inflammatory diseases .
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP003463 ECSP003463A (en) | 2000-05-02 | 2000-05-02 | USEFUL PIPERIDINE DERIVATIVES AS CCR5 ANTAGONISTS |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP003463 ECSP003463A (en) | 2000-05-02 | 2000-05-02 | USEFUL PIPERIDINE DERIVATIVES AS CCR5 ANTAGONISTS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP003463A true ECSP003463A (en) | 2000-12-19 |
Family
ID=42041090
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP003463 ECSP003463A (en) | 2000-05-02 | 2000-05-02 | USEFUL PIPERIDINE DERIVATIVES AS CCR5 ANTAGONISTS |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP003463A (en) |
-
2000
- 2000-05-02 EC ECSP003463 patent/ECSP003463A/en unknown
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