EA202192497A1 - Методы лечения органических ацидемий - Google Patents
Методы лечения органических ацидемийInfo
- Publication number
- EA202192497A1 EA202192497A1 EA202192497A EA202192497A EA202192497A1 EA 202192497 A1 EA202192497 A1 EA 202192497A1 EA 202192497 A EA202192497 A EA 202192497A EA 202192497 A EA202192497 A EA 202192497A EA 202192497 A1 EA202192497 A1 EA 202192497A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- methods
- treatment
- coa
- organic acidemia
- acidemia
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Настоящее изобретение относится к способам лечения органических ацидемий. В некоторых вариантах осуществления способы включают снижение выработки пропионил-КоА, изовалерил-КоА и метилмалонил-КоА и различных родственных метаболитов у субъекта, нуждающегося в этом.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962818372P | 2019-03-14 | 2019-03-14 | |
PCT/US2020/022760 WO2020186216A1 (en) | 2019-03-14 | 2020-03-13 | Methods of treating organic acidemias |
Publications (1)
Publication Number | Publication Date |
---|---|
EA202192497A1 true EA202192497A1 (ru) | 2021-11-18 |
Family
ID=72426817
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA202192497A EA202192497A1 (ru) | 2019-03-14 | 2020-03-13 | Методы лечения органических ацидемий |
Country Status (11)
Country | Link |
---|---|
US (1) | US20220142955A1 (ru) |
EP (1) | EP3937922A4 (ru) |
JP (1) | JP2022525339A (ru) |
KR (1) | KR20210139274A (ru) |
CN (1) | CN113557014A (ru) |
AU (1) | AU2020236023A1 (ru) |
BR (1) | BR112021018036A2 (ru) |
CA (1) | CA3133260A1 (ru) |
EA (1) | EA202192497A1 (ru) |
IL (1) | IL285822A (ru) |
WO (1) | WO2020186216A1 (ru) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2022216848A1 (en) * | 2021-04-06 | 2022-10-13 | Hemoshear Therapeutics, Inc. | Methods of treating methylmalonic acidemia and propionic acidemia |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1249706B (it) * | 1991-09-18 | 1995-03-09 | Sigma Tau Ind Farmaceuti | Uso di l-carnitina nella gravidanza a rischio. |
US20050027006A1 (en) * | 2003-07-28 | 2005-02-03 | Reuben Matalon | Methods and materials for treating conditions associated with metabolic disorders |
WO2011072086A1 (en) * | 2009-12-08 | 2011-06-16 | Hemaquest Pharmaceuticals, Inc. | Methods and low dose regimens for treating red blood cell disorders |
US20120289476A1 (en) * | 2009-12-11 | 2012-11-15 | Jay Allan Barth | Methods for treating methylmalonic acidemia |
US9018176B2 (en) * | 2010-12-02 | 2015-04-28 | Susan Perrine | Inducers of hematopoiesis and fetal globin production for treatment of cytopenias and hemoglobin disorders |
US9790184B2 (en) * | 2012-07-27 | 2017-10-17 | The Broad Institute, Inc. | Inhibitors of histone deacetylase |
WO2017139697A1 (en) * | 2016-02-10 | 2017-08-17 | Synlogic, Inc. | Bacteria engineered to treat diseases associated with hyperammonemia |
WO2017184583A1 (en) * | 2016-04-19 | 2017-10-26 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Anaplerotic agents for treatment of disorders of propionate and long chain fat metabolism |
-
2020
- 2020-03-13 CA CA3133260A patent/CA3133260A1/en active Pending
- 2020-03-13 EA EA202192497A patent/EA202192497A1/ru unknown
- 2020-03-13 KR KR1020217029827A patent/KR20210139274A/ko active Search and Examination
- 2020-03-13 US US17/438,560 patent/US20220142955A1/en active Pending
- 2020-03-13 BR BR112021018036A patent/BR112021018036A2/pt unknown
- 2020-03-13 AU AU2020236023A patent/AU2020236023A1/en not_active Abandoned
- 2020-03-13 WO PCT/US2020/022760 patent/WO2020186216A1/en active Application Filing
- 2020-03-13 CN CN202080020521.7A patent/CN113557014A/zh active Pending
- 2020-03-13 EP EP20770425.5A patent/EP3937922A4/en active Pending
- 2020-03-13 JP JP2021555384A patent/JP2022525339A/ja active Pending
-
2021
- 2021-08-24 IL IL285822A patent/IL285822A/en unknown
Also Published As
Publication number | Publication date |
---|---|
JP2022525339A (ja) | 2022-05-12 |
CN113557014A (zh) | 2021-10-26 |
KR20210139274A (ko) | 2021-11-22 |
US20220142955A1 (en) | 2022-05-12 |
WO2020186216A1 (en) | 2020-09-17 |
EP3937922A1 (en) | 2022-01-19 |
IL285822A (en) | 2021-10-31 |
EP3937922A4 (en) | 2022-11-30 |
CA3133260A1 (en) | 2020-09-17 |
BR112021018036A2 (pt) | 2021-11-23 |
AU2020236023A1 (en) | 2021-11-04 |
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