EA202192299A1 - VARIANT NUCLEIC ACID LIBRARIES FOR ANTIBODY OPTIMIZATION - Google Patents
VARIANT NUCLEIC ACID LIBRARIES FOR ANTIBODY OPTIMIZATIONInfo
- Publication number
- EA202192299A1 EA202192299A1 EA202192299A EA202192299A EA202192299A1 EA 202192299 A1 EA202192299 A1 EA 202192299A1 EA 202192299 A EA202192299 A EA 202192299A EA 202192299 A EA202192299 A EA 202192299A EA 202192299 A1 EA202192299 A1 EA 202192299A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- libraries
- nucleic acid
- acid libraries
- variant nucleic
- antibody optimization
- Prior art date
Links
Abstract
В настоящем документе представлены способы и композиции, относящиеся к библиотекам оптимизированных антител, содержащих нуклеиновые кислоты, кодирующие антитело, содержащее модифицированные последовательности. Описанные в настоящем документе библиотеки включают в себя разнообразные библиотеки, содержащие нуклеиновые кислоты, каждая из которых кодирует предварительно определенный вариант по меньшей мере одной предварительно определенной эталонной последовательности нуклеиновой кислоты. Дополнительно в настоящем документе описаны библиотеки белков, полученные при трансляции библиотек нуклеиновых кислот. Дополнительно в настоящем документе описаны библиотеки клеток, экспрессирующие разнообразные библиотеки нуклеиновых кислот, описанные в настоящем документе.This document provides methods and compositions related to libraries of optimized antibodies containing nucleic acids encoding an antibody containing modified sequences. The libraries described herein include a variety of libraries containing nucleic acids, each of which encodes a predefined variant of at least one predefined reference nucleic acid sequence. Additionally, protein libraries derived from translation of nucleic acid libraries are described herein. Additionally, cell libraries expressing the various nucleic acid libraries described herein are described herein.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962830296P | 2019-04-05 | 2019-04-05 | |
| PCT/US2020/019988 WO2020176680A1 (en) | 2019-02-26 | 2020-02-26 | Variant nucleic acid libraries for antibody optimization |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA202192299A1 true EA202192299A1 (en) | 2022-02-09 |
Family
ID=80631317
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA202192299A EA202192299A1 (en) | 2019-04-05 | 2020-02-26 | VARIANT NUCLEIC ACID LIBRARIES FOR ANTIBODY OPTIMIZATION |
Country Status (1)
| Country | Link |
|---|---|
| EA (1) | EA202192299A1 (en) |
-
2020
- 2020-02-26 EA EA202192299A patent/EA202192299A1/en unknown
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