EA202192170A1 - THIENO [3,2-b] PYRIDINE-7-AMINE COMPOUNDS FOR THE TREATMENT OF FAMILY VEGETOVASCULAR DYSTONIA - Google Patents

THIENO [3,2-b] PYRIDINE-7-AMINE COMPOUNDS FOR THE TREATMENT OF FAMILY VEGETOVASCULAR DYSTONIA

Info

Publication number
EA202192170A1
EA202192170A1 EA202192170A EA202192170A EA202192170A1 EA 202192170 A1 EA202192170 A1 EA 202192170A1 EA 202192170 A EA202192170 A EA 202192170A EA 202192170 A EA202192170 A EA 202192170A EA 202192170 A1 EA202192170 A1 EA 202192170A1
Authority
EA
Eurasian Patent Office
Prior art keywords
treatment
pyridine
thieno
family
amine compounds
Prior art date
Application number
EA202192170A
Other languages
Russian (ru)
Inventor
Наньцзин Чжан
Майкл А. Арнольд
Амал Дакка
Гари Митчелл Кэрп
Том Туан Луонг
Джейна Нарэсимхен
Николай А. Нарышкин
Цзяши Ван
Сяоянь Чжан
Original Assignee
ПиТиСи ТЕРАПЬЮТИКС, ИНК.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ПиТиСи ТЕРАПЬЮТИКС, ИНК. filed Critical ПиТиСи ТЕРАПЬЮТИКС, ИНК.
Publication of EA202192170A1 publication Critical patent/EA202192170A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Abstract

Изобретение относится к соединениям формулы (I), применимым для улучшения сплайсинга пре-мРНК в клетке. В частности, другой аспект изобретения относится к замещенным тиено[3,2-b]пиридиновым соединениям, их формам и фармацевтическим композициям, а также к способам применения для лечения или облегчения семейной вегето-сосудистой дистонии.The invention relates to compounds of formula (I) useful for improving pre-mRNA splicing in a cell. In particular, another aspect of the invention relates to substituted thieno [3,2-b] pyridine compounds, their forms and pharmaceutical compositions, as well as methods of use for the treatment or amelioration of familial vegetative-vascular dystonia.

EA202192170A 2019-02-13 2020-02-10 THIENO [3,2-b] PYRIDINE-7-AMINE COMPOUNDS FOR THE TREATMENT OF FAMILY VEGETOVASCULAR DYSTONIA EA202192170A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962805283P 2019-02-13 2019-02-13
PCT/US2020/017430 WO2020167628A1 (en) 2019-02-13 2020-02-10 Thioeno[3,2-b] pyridin-7-amine compounds for treating familial dysautonomia

Publications (1)

Publication Number Publication Date
EA202192170A1 true EA202192170A1 (en) 2021-11-15

Family

ID=69960696

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202192170A EA202192170A1 (en) 2019-02-13 2020-02-10 THIENO [3,2-b] PYRIDINE-7-AMINE COMPOUNDS FOR THE TREATMENT OF FAMILY VEGETOVASCULAR DYSTONIA

Country Status (16)

Country Link
US (1) US20220135586A1 (en)
EP (1) EP3924049A1 (en)
JP (1) JP2022520822A (en)
KR (1) KR20210137040A (en)
CN (1) CN113795304A (en)
AU (1) AU2020222881A1 (en)
BR (1) BR112021015853A2 (en)
CA (1) CA3129067A1 (en)
CL (1) CL2021002137A1 (en)
CO (1) CO2021010598A2 (en)
EA (1) EA202192170A1 (en)
IL (1) IL285399A (en)
MX (1) MX2021009667A (en)
PE (1) PE20220139A1 (en)
SG (1) SG11202108519TA (en)
WO (1) WO2020167628A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2022013856A (en) 2020-05-13 2023-04-05 Chdi Foundation Inc Htt modulators for treating huntington's disease.
WO2022155427A1 (en) * 2021-01-14 2022-07-21 Georgetown University Usp13 inhibitors and methods of use thereof
CN112920053B (en) * 2021-02-01 2022-07-01 暨明医药科技（苏州）有限公司 Preparation method of chiral alpha-methyl aromatic ethylamine
EP4288054A1 (en) * 2021-02-05 2023-12-13 PTC Therapeutics, Inc. Methods for treating spinocerebellar ataxia type 3
US20240043444A1 (en) * 2021-02-05 2024-02-08 Ptc Therapeutics, Inc. Methods for treating spinocerebellar ataxia type 3
CN117715908A (en) 2021-06-03 2024-03-15 江苏恒瑞医药股份有限公司 Pyridone compounds having integrase inhibitory activity and their pharmaceutical use
CA3231007A1 (en) * 2021-09-07 2023-03-16 Scott J. Barraza Methods for treating neurogenerative diseases
WO2023081860A1 (en) * 2021-11-04 2023-05-11 Skyhawk Therapeutics, Inc. Triazine amino derivatives for treating sca3
WO2023212239A1 (en) 2022-04-27 2023-11-02 Skyhawk Therapeutics, Inc. Compositions useful for modulating splicing
WO2023220439A1 (en) 2022-05-12 2023-11-16 Skyhawk Therapeutics, Inc. Compositions useful for modulating splicing
WO2023250316A1 (en) * 2022-06-22 2023-12-28 Ptc Therapeutics, Inc. Compounds for treating spinocerebellar ataxia type 3
WO2024036143A2 (en) * 2022-08-09 2024-02-15 Ptc Therapeutics, Inc. Methods for modulating rna splicing

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2015005491A1 (en) * 2013-07-12 2017-03-02 国立大学法人京都大学 Screening method for substances capable of suppressing abnormal splicing that contributes to the onset or progression of disease
PL3244891T3 (en) 2015-01-16 2022-12-27 The General Hospital Corporation Compounds for improving mrna splicing

Also Published As

Publication number Publication date
MX2021009667A (en) 2021-12-10
JP2022520822A (en) 2022-04-01
PE20220139A1 (en) 2022-01-27
WO2020167628A1 (en) 2020-08-20
CO2021010598A2 (en) 2021-08-30
EP3924049A1 (en) 2021-12-22
SG11202108519TA (en) 2021-09-29
IL285399A (en) 2021-09-30
BR112021015853A2 (en) 2021-10-05
CA3129067A1 (en) 2020-08-20
KR20210137040A (en) 2021-11-17
CN113795304A (en) 2021-12-14
AU2020222881A1 (en) 2021-09-09
US20220135586A1 (en) 2022-05-05
CL2021002137A1 (en) 2022-02-25

Similar Documents

Publication Publication Date Title
EA202192170A1 (en) THIENO [3,2-b] PYRIDINE-7-AMINE COMPOUNDS FOR THE TREATMENT OF FAMILY VEGETOVASCULAR DYSTONIA
EA201591965A1 (en) Derivatives of benzimidazole as bromodomain inhibitors
AU2016361478A8 (en) Bivalent bromodomain inhibitors and uses thereof
EA201992584A1 (en) NEW MAP4K1 INHIBITORS
EA201800367A1 (en) METHODS OF TREATMENT OF HUNTINGTON'S DISEASE
EA201100604A1 (en) CONNECTIONS OF PERIDEL INHIBITORS OF TRANSMISSION OF SIGNALS BY HEDGEHOG PROTEIN, METHOD OF THEIR RECEIVING, COMPOSITION AND METHODS OF TREATING CANCER AND INHIBITING ANGIOGENESIS AND HEDGEHOG IN CELLS
BR112012017269A2 (en) tricyclic heterocyclic compounds, compositions and methods of use thereof
EA201792214A1 (en) COMPOUNDS OF SUBSTITUTE QUINAZOLINE
EA202092490A1 (en) METHYL-MODIFYING ENZYMES MODULATORS, COMPOSITIONS AND THEIR APPLICATION
CY1123689T1 (en) LORLATINIB FREE BASE CRYSTAL FORM
EA201200951A1 (en) CERTAIN TRIAZOLOPIRIDINES AND TRIAZOLOPIRASINS, THEIR COMPOSITIONS AND METHODS OF THEIR APPLICATION
EA201790267A1 (en) NEW KINAZ MODULATORS
EA200800760A1 (en) PYRIDOPYRIMIDINONE INHIBITORS PI3Kα
EA201692166A1 (en) GLETAMINASE HETEROCYCLIC INHIBITORS
EA200870127A1 (en) POLYCYCLIC DERIVATIVES OF AMINO ACIDS AND METHODS OF THEIR APPLICATION
EA202091530A1 (en) DIAZAINDOL CONNECTIONS
EA201792034A1 (en) SUBSTITUTED TRICYCLIC HETEROCYCLIC COMPOUNDS
EA201000642A1 (en) 2'-FLUOR-2'-DEOXYTETRAHYDROUridine AS CYTIDINDE DIAMINASE INHIBITORS
EA200501676A1 (en) PHOSPHONATE-CONTAINING KINASE INHIBITORS (OPTIONS), METHOD FOR THEIR RECEIVING, PHARMACEUTICAL COMPOSITION, PHARMACEUTICAL FORM ON THEIR BASIS AND METHOD FOR INHIBING KINASE IN MOLOPYTIC TREATMENT THEM
EA200800374A1 (en) 1,4-DIHYDROPYRIDIN-CONDENSED HETEROCYCLES, METHODS FOR THEIR PRODUCTION, USE AND CONTAINING COMPOSITIONS
EA201290980A1 (en) DERIVATIVES OF 1-AMINO-2-CYCLOPROPYLETHYLBURONIC ACID
EA202092086A1 (en) ARGINASE INHIBITORS
EA201270339A1 (en) SUBSTITUTED DERIVATIVES OF XANTHINE
EA201170508A1 (en) DERIVATIVES OF 1-AMINO-2-CYCLOBUTYLETHYLBURONIC ACID
EA201690135A1 (en) TRICYCLIC COMPOUNDS OF BENZOXOBOROL AND THEIR APPLICATION