EA202191885A3 - BICYCLIC HETEROCYCLIC DERIVATIVES AS IRAK4 INHIBITORS - Google Patents

BICYCLIC HETEROCYCLIC DERIVATIVES AS IRAK4 INHIBITORS

Info

Publication number
EA202191885A3
EA202191885A3 EA202191885A EA202191885A EA202191885A3 EA 202191885 A3 EA202191885 A3 EA 202191885A3 EA 202191885 A EA202191885 A EA 202191885A EA 202191885 A EA202191885 A EA 202191885A EA 202191885 A3 EA202191885 A3 EA 202191885A3
Authority
EA
Eurasian Patent Office
Prior art keywords
inhibitors
bicyclic heterocyclic
irak4
kinase
heterocyclic derivatives
Prior art date
Application number
EA202191885A
Other languages
Russian (ru)
Other versions
EA202191885A2 (en
Inventor
Венкатешвар Рао Гуммади
Сусанта Самадждар
Original Assignee
Ориджин Дискавери Текнолоджиз Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ориджин Дискавери Текнолоджиз Лимитед filed Critical Ориджин Дискавери Текнолоджиз Лимитед
Publication of EA202191885A2 publication Critical patent/EA202191885A2/en
Publication of EA202191885A3 publication Critical patent/EA202191885A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Изобретение относится к бициклическим гетероциклическим соединениям ингибиторам ферментов киназ формулы (I), которые являются терапевтически полезным в качестве ингибиторов киназы, в частности ингибиторов IRAK4где A, Y, Z, X1, X2, X3, R1, R3, m, n и p имеют значения, указанные в описании, и их фармацевтически приемлемым солям или стереоизомерам, которые могут быть использованы для лечения и профилактики заболеваний или расстройств, в частности их применению при заболеваниях или расстройствах, опосредованных киназным ферментом, в частности ферментом IRAK4. Настоящее изобретение относится также к фармацевтической композиции, содержащей по меньшей мере одно соединение формулы (I) вместе с фармацевтически приемлемым носителем, разбавителем или вспомогательным веществом.The invention relates to bicyclic heterocyclic compounds inhibitors of kinase enzymes of formula (I), which are therapeutically useful as kinase inhibitors, in particular IRAK4 inhibitors, where A, Y, Z, X1, X2, X3, R1, R3, m, n and p are , specified in the description, and their pharmaceutically acceptable salts or stereoisomers, which can be used for the treatment and prevention of diseases or disorders, in particular their use in diseases or disorders mediated by a kinase enzyme, in particular the IRAK4 enzyme. The present invention also relates to a pharmaceutical composition containing at least one compound of formula (I) together with a pharmaceutically acceptable carrier, diluent or excipient.

EA202191885A 2014-06-20 2015-01-12 BICYCLIC HETEROCYCLIC DERIVATIVES AS IRAK4 INHIBITORS EA202191885A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN3000CH2014 2014-06-20

Publications (2)

Publication Number Publication Date
EA202191885A2 EA202191885A2 (en) 2021-10-29
EA202191885A3 true EA202191885A3 (en) 2022-01-31

Family

ID=78572610

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202191885A EA202191885A3 (en) 2014-06-20 2015-01-12 BICYCLIC HETEROCYCLIC DERIVATIVES AS IRAK4 INHIBITORS

Country Status (1)

Country Link
EA (1) EA202191885A3 (en)

Also Published As

Publication number Publication date
EA202191885A2 (en) 2021-10-29

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