EA202191499A1 - Системы и способы способствования клональной селекции - Google Patents

Системы и способы способствования клональной селекции

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Publication number
EA202191499A1
EA202191499A1 EA202191499A EA202191499A EA202191499A1 EA 202191499 A1 EA202191499 A1 EA 202191499A1 EA 202191499 A EA202191499 A EA 202191499A EA 202191499 A EA202191499 A EA 202191499A EA 202191499 A1 EA202191499 A1 EA 202191499A1
Authority
EA
Eurasian Patent Office
Prior art keywords
image
colony
processor
systems
methods
Prior art date
Application number
EA202191499A
Other languages
English (en)
Inventor
Ю Юань
Грэхем Ф. Милн
Тони И. Ван
Кин Х. Ле
Гленн Тан
Original Assignee
Эмджен Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эмджен Инк. filed Critical Эмджен Инк.
Publication of EA202191499A1 publication Critical patent/EA202191499A1/ru

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Classifications

    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • G06V20/695—Preprocessing, e.g. image segmentation
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F18/00—Pattern recognition
    • G06F18/20—Analysing
    • G06F18/24—Classification techniques
    • G06F18/241—Classification techniques relating to the classification model, e.g. parametric or non-parametric approaches
    • G06F18/2413—Classification techniques relating to the classification model, e.g. parametric or non-parametric approaches based on distances to training or reference patterns
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00—Computing arrangements based on biological models
    • G06N3/02—Neural networks
    • G06N3/04—Architecture, e.g. interconnection topology
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V10/00—Arrangements for image or video recognition or understanding
    • G06V10/70—Arrangements for image or video recognition or understanding using pattern recognition or machine learning
    • G06V10/764—Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V10/00—Arrangements for image or video recognition or understanding
    • G06V10/70—Arrangements for image or video recognition or understanding using pattern recognition or machine learning
    • G06V10/82—Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • G06V20/693—Acquisition
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • G06V20/698—Matching; Classification

Landscapes

  • Engineering & Computer Science (AREA)
  • Theoretical Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Multimedia (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Evolutionary Computation (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Artificial Intelligence (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Data Mining & Analysis (AREA)
  • Software Systems (AREA)
  • Computing Systems (AREA)
  • Databases & Information Systems (AREA)
  • Medical Informatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Biophysics (AREA)
  • Computational Linguistics (AREA)
  • Mathematical Physics (AREA)
  • Image Processing (AREA)
  • Image Analysis (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

Способ способствования клональной селекции включает генерирование изображений временной последовательности лунки, содержащей среду, содержащих первое изображение и более позднее второе изображение. Способ также включает обнаружение одним или несколькими процессорами, анализирующими первое изображение, одного или нескольких объектов-кандидатов, изображенных на первом изображении, и для каждого из объектов-кандидатов определение того, является ли объект одиночной клеткой, путем анализа изображения объекта с использованием сверточной нейронной сети. Способ дополнительно включает обнаружение путем анализа второго изображения процессором (процессорами) колонии клеток, изображенной на втором изображении, и определение процессором (процессорами) того, была ли колония образована только из одной клетки, по меньшей мере частично на основании того, был ли каждый объект-кандидат определен в качестве одиночной клетки. Способ дополнительно включает генерирование процессором (процессорами) выходных данных, указывающих на то, была ли колония образована только из одной клетки.
EA202191499A 2018-11-30 2019-11-26 Системы и способы способствования клональной селекции EA202191499A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862774154P 2018-11-30 2018-11-30
PCT/US2019/063177 WO2020112723A1 (en) 2018-11-30 2019-11-26 Systems and methods for facilitating clone selection

Publications (1)

Publication Number Publication Date
EA202191499A1 true EA202191499A1 (ru) 2021-08-20

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EA202191499A EA202191499A1 (ru) 2018-11-30 2019-11-26 Системы и способы способствования клональной селекции

Country Status (14)

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US (1) US20220012465A1 (ru)
EP (1) EP3888004A1 (ru)
JP (1) JP2022509201A (ru)
KR (1) KR20210099028A (ru)
CN (1) CN113168519A (ru)
AU (1) AU2019387079B2 (ru)
BR (1) BR112021010404A2 (ru)
CA (1) CA3120281A1 (ru)
CL (1) CL2021001409A1 (ru)
EA (1) EA202191499A1 (ru)
IL (1) IL283577A (ru)
MX (1) MX2021005938A (ru)
SG (1) SG11202105399RA (ru)
WO (1) WO2020112723A1 (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3173976A1 (en) 2020-03-06 2021-09-10 Amgen Inc. Systems and methods for assessing cell growth rates
US20220327863A1 (en) * 2021-04-12 2022-10-13 Bitsensing Inc. Face identification using millimeter-wave radar sensor data
WO2024161784A1 (ja) * 2023-01-30 2024-08-08 富士フイルム株式会社 判定支援装置、判定支援装置の作動方法、および判定支援装置の作動プログラム

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19616997A1 (de) * 1996-04-27 1997-10-30 Boehringer Mannheim Gmbh Verfahren zur automatisierten mikroskopunterstützten Untersuchung von Gewebeproben oder Körperflüssigkeitsproben
US6753161B2 (en) * 1997-03-27 2004-06-22 Oncosis Llc Optoinjection methods
JPWO2011016189A1 (ja) * 2009-08-07 2013-01-10 株式会社ニコン 細胞の分類手法、この手法を用いた画像処理プログラム及び画像処理装置、並びに細胞塊の製造方法
EP2682187B1 (en) * 2012-07-02 2017-09-13 Molecular Devices, LLC Selection method and apparatus
EP2708890B1 (en) * 2012-09-14 2015-11-18 Molecular Devices (New Milton) Ltd Method of selecting a monoclonal cell colony
US9619881B2 (en) * 2013-09-26 2017-04-11 Cellogy, Inc. Method and system for characterizing cell populations
WO2015080001A1 (ja) * 2013-11-27 2015-06-04 大日本印刷株式会社 培地情報登録システム、コロニー検出装置、プログラム及び衛生管理システム
SI3304037T1 (sl) * 2015-06-02 2020-03-31 Baxalta Incorporated Postopek za odbiranje kolonije celic
WO2018213709A1 (en) * 2017-05-19 2018-11-22 Thrive Bioscience, Inc. Systems and methods for counting cells
GB2576191B (en) * 2018-08-08 2022-11-16 Sphere Fluidics Ltd Droplet processing methods and systems

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Publication number Publication date
CL2021001409A1 (es) 2021-11-12
KR20210099028A (ko) 2021-08-11
CN113168519A (zh) 2021-07-23
SG11202105399RA (en) 2021-06-29
CA3120281A1 (en) 2020-06-04
MX2021005938A (es) 2021-06-30
EP3888004A1 (en) 2021-10-06
IL283577A (en) 2021-07-29
JP2022509201A (ja) 2022-01-20
WO2020112723A1 (en) 2020-06-04
AU2019387079B2 (en) 2024-08-01
BR112021010404A2 (pt) 2021-08-24
US20220012465A1 (en) 2022-01-13
AU2019387079A1 (en) 2021-06-03

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