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Application filed by Айовэнс Байотерапьютикс, Инк.filedCriticalАйовэнс Байотерапьютикс, Инк.
Priority claimed from PCT/US2019/059716external-prioritypatent/WO2020096986A2/en
Publication of EA202191263A1publicationCriticalpatent/EA202191263A1/en
Medicines Containing Material From Animals Or Micro-Organisms
(AREA)
Abstract
В настоящем изобретении предложены способы предварительного отбора TIL на основе экспрессии PD-1, а также способы экспансии указанных предварительно отобранных положительных по PD-1 TIL для получения терапевтических популяций TIL с повышенной способностью к уничтожению опухоли (например, повышенной цитотоксичностью).The present invention provides methods for pre-selecting TILs based on PD-1 expression, as well as methods for expanding said pre-selected PD-1 positive TILs to generate therapeutic populations of TILs with increased tumor killing capacity (eg, increased cytotoxicity).
EA202191263A2019-10-222019-11-04
SELECTION OF IMPROVED TUMOR-REACTIVE T-CELLS
EA202191263A1
(en)