EA202191138A1 - COMPOSITIONS AND METHODS FOR INHIBITING ARGINASE ACTIVITY - Google Patents

COMPOSITIONS AND METHODS FOR INHIBITING ARGINASE ACTIVITY

Info

Publication number
EA202191138A1
EA202191138A1 EA202191138A EA202191138A EA202191138A1 EA 202191138 A1 EA202191138 A1 EA 202191138A1 EA 202191138 A EA202191138 A EA 202191138A EA 202191138 A EA202191138 A EA 202191138A EA 202191138 A1 EA202191138 A1 EA 202191138A1
Authority
EA
Eurasian Patent Office
Prior art keywords
methods
compositions
arginase activity
inhibiting arginase
compounds
Prior art date
Application number
EA202191138A
Other languages
Russian (ru)
Inventor
Эрик Б. Сьегрен
Джим Ли
Майкл Ван Зандт
Даррен Уайтхаус
Original Assignee
Калитера Байосайенсиз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Калитера Байосайенсиз, Инк. filed Critical Калитера Байосайенсиз, Инк.
Publication of EA202191138A1 publication Critical patent/EA202191138A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/04—Esters of boric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Изобретение относится к новому классу соединений, которые демонстрируют ингибиторную активность в отношении аргиназы, и фармацевтическим композициям, включающим соединения по изобретению. Также в настоящей заявке представлены способы лечения рака ингибиторами аргиназы по изобретению.The invention relates to a new class of compounds that exhibit arginase inhibitory activity and pharmaceutical compositions comprising the compounds of the invention. Also provided herein are methods of treating cancer with arginase inhibitors of the invention.

EA202191138A 2016-04-15 2016-10-28 COMPOSITIONS AND METHODS FOR INHIBITING ARGINASE ACTIVITY EA202191138A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662323034P 2016-04-15 2016-04-15

Publications (1)

Publication Number Publication Date
EA202191138A1 true EA202191138A1 (en) 2022-03-31

Family

ID=81075143

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202191138A EA202191138A1 (en) 2016-04-15 2016-10-28 COMPOSITIONS AND METHODS FOR INHIBITING ARGINASE ACTIVITY

Country Status (1)

Country Link
EA (1) EA202191138A1 (en)

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