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Application filed by Транслейт Био, Инк.filedCriticalТранслейт Био, Инк.
Priority claimed from PCT/US2019/060344external-prioritypatent/WO2020097384A1/en
Publication of EA202190894A1publicationCriticalpatent/EA202190894A1/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
Изобретение частично предусматривает липидные соединения на основе циклической аминокислоты формулы (A') и ее подформул или ее фармацевтически приемлемой соли. Соединения, предусмотренные в данном документе, могут быть применимыми для доставки и экспрессии mRNA и кодируемого белка, например, в качестве компонента липосомальной среды-носителя для доставки и, соответственно, могут быть применимыми для лечения разнообразных заболеваний, нарушений и состояний, таких как заболевания, нарушения и состояния, ассоциированные с дефицитом одного или более белков.The invention provides, in part, lipid compounds based on a cyclic amino acid of formula (A ') and sub-formulas thereof, or a pharmaceutically acceptable salt thereof. The compounds provided herein may be useful for the delivery and expression of mRNA and encoded protein, for example, as a component of a liposomal delivery vehicle and, accordingly, may be useful for the treatment of a variety of diseases, disorders and conditions such as diseases, disorders and conditions associated with a deficiency of one or more proteins.
EA202190894A2019-07-082019-11-07
LIPIDS BASED ON 2,5-DIOXOPIPERAZINE CONTAINING INTERCALATED ESTER, THIOESTER, DISULPHIDE AND ANHYDRIDE FRAGMENTS
EA202190894A1
(en)
compositions and methods comprising prostaglandin-related compounds and trifoliate factor family peptides for the treatment of glaucoma with reduced hyperemia
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