EA202092850A1 - ANTIBODIES BINDING VISTA AT ACID pH - Google Patents

ANTIBODIES BINDING VISTA AT ACID pH

Info

Publication number
EA202092850A1
EA202092850A1 EA202092850A EA202092850A EA202092850A1 EA 202092850 A1 EA202092850 A1 EA 202092850A1 EA 202092850 A EA202092850 A EA 202092850A EA 202092850 A EA202092850 A EA 202092850A EA 202092850 A1 EA202092850 A1 EA 202092850A1
Authority
EA
Eurasian Patent Office
Prior art keywords
vista
acid
antibodies binding
antibodies
acidic
Prior art date
Application number
EA202092850A
Other languages
Russian (ru)
Inventor
Роберт Дж. Джонстон
Арвинд РАДЖПАЛ
Пол О. Шеппард
Луис Боргес
Эндрю Рэнкин
Кейт Садун Бахджат
Алан Дж. Корман
Сяоди Ден
Линь Хой Су
Джинджер Рэйкстро
Джейсон Р. Пинкни
Дэвид А. Криттон
Годун Чэнь
Ричард Й. Хуанг
Екатерина Г. Деянова
Майкл Куигли
Хадиа Лемар
Акбар Найим
Original Assignee
Файв Прайм Терапьютикс, Инк.
Бристол-Маерс Сквибб Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Файв Прайм Терапьютикс, Инк., Бристол-Маерс Сквибб Компани filed Critical Файв Прайм Терапьютикс, Инк.
Priority claimed from PCT/US2019/041154 external-priority patent/WO2020014327A2/en
Publication of EA202092850A1 publication Critical patent/EA202092850A1/en

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Abstract

Настоящая заявка относится к антителам, специфически связывающимся с содержащим V-домен иммуноглобулина супрессором активации Т-клеток (VISTA) при кислом рН, и их применению в лечении рака. В некоторых вариантах осуществления антитела специфически связываются с VISTA человека при кислом рН, но не связываются значительно с VISTA человека при нейтральном или физиологическом рН.The present application relates to antibodies that specifically bind to an immunoglobulin V-domain containing T cell activation suppressor (VISTA) at acidic pH and their use in the treatment of cancer. In some embodiments, the antibodies specifically bind to human VISTA at acidic pH, but do not significantly bind to human VISTA at neutral or physiological pH.

EA202092850A 2019-03-29 2019-07-10 ANTIBODIES BINDING VISTA AT ACID pH EA202092850A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962826330P 2019-03-29 2019-03-29
PCT/US2019/041154 WO2020014327A2 (en) 2018-07-11 2019-07-10 Antibodies binding to vista at acidic ph

Publications (1)

Publication Number Publication Date
EA202092850A1 true EA202092850A1 (en) 2021-06-17

Family

ID=76807396

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202092850A EA202092850A1 (en) 2019-03-29 2019-07-10 ANTIBODIES BINDING VISTA AT ACID pH

Country Status (1)

Country Link
EA (1) EA202092850A1 (en)

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