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Application filed by Форма Терапьютикс, Инк.filedCriticalФорма Терапьютикс, Инк.
Priority claimed from PCT/US2019/032619external-prioritypatent/WO2019222468A1/en
Publication of EA202092756A1publicationCriticalpatent/EA202092756A1/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Nitrogen Condensed Heterocyclic Rings
(AREA)
Abstract
Настоящее изобретение относится к соединениям формулы (I') и их фармацевтически приемлемым солям, применяемым в качестве ингибиторов убиквитин-специфической пептидазы 30 (USP30), к их фармацевтическим композициям и к способам их применения. Раскрытые в изобретении соединения могут применяться при лечении заболевания или нарушения, связанного с митохондриальной дисфункцией, в том числе нейродегенеративных заболеваний.The present invention relates to compounds of formula (I ') and their pharmaceutically acceptable salts used as inhibitors of ubiquitin-specific peptidase 30 (USP30), to their pharmaceutical compositions and to methods of using them. The compounds disclosed in the invention can be used in the treatment of a disease or disorder associated with mitochondrial dysfunction, including neurodegenerative diseases.
EA202092756A2018-09-052019-05-16
CONDENSED BICYCLIC COMPOUNDS FOR USE AS UBIKVITIN-SPECIFIC PEPTIDASE INHIBITORS 30
EA202092756A1
(en)