EA202092507A1 - DE NOVO MODELING OF EFFECTIVE AND SELECTIVE INTERLEUKIN MIMETICS - Google Patents

DE NOVO MODELING OF EFFECTIVE AND SELECTIVE INTERLEUKIN MIMETICS

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Publication number
EA202092507A1
EA202092507A1 EA202092507A EA202092507A EA202092507A1 EA 202092507 A1 EA202092507 A1 EA 202092507A1 EA 202092507 A EA202092507 A EA 202092507A EA 202092507 A EA202092507 A EA 202092507A EA 202092507 A1 EA202092507 A1 EA 202092507A1
Authority
EA
Eurasian Patent Office
Prior art keywords
mimetics
effective
novo
modeling
selective interleukin
Prior art date
Application number
EA202092507A
Other languages
Russian (ru)
Inventor
Даниэль Адриано Сильва Манцано
Шон Юй
Умут Ульге
Дэвид Бейкер
Кенан Кристофер Гарсия
Джейми Спенглер
Карл Уоки
Альфредо Кихано Рубио
Кевин Джуд
Брайан Вайцнер
Энрике Маркос
Хавьер Кастельянос
Original Assignee
Юниверсити Оф Вашингтон
Зе Борд Оф Трастис Оф Зе Леланд Стэнфорд Джуниор Юниверсити
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Юниверсити Оф Вашингтон, Зе Борд Оф Трастис Оф Зе Леланд Стэнфорд Джуниор Юниверсити filed Critical Юниверсити Оф Вашингтон
Priority claimed from PCT/US2019/038703 external-priority patent/WO2020005819A1/en
Publication of EA202092507A1 publication Critical patent/EA202092507A1/en

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  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Раскрыты моделируемые de novo ("заново") полипептиды, которые связываются с гетеродимером Ɣc рецептора IL-2 (IL-2RƔc), гетеродимером Ɣc рецептора IL-4 (IL-4RƔc) или с -субъединицей рецептора IL-13 (IL-13R), а также способы применения и моделирования указанных полипептидов.Disclosed are de novo modeled polypeptides that bind to IL-2 receptor αc heterodimer (IL-2RƔc), IL-4 receptor βc heterodimer (IL-4RƔc) or IL-13 receptor β-subunit (IL-13R) as well as methods of using and modeling said polypeptides.

EA202092507A 2018-11-16 2019-06-24 DE NOVO MODELING OF EFFECTIVE AND SELECTIVE INTERLEUKIN MIMETICS EA202092507A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862768733P 2018-11-16 2018-11-16
PCT/US2019/038703 WO2020005819A1 (en) 2018-06-25 2019-06-24 De novo design of potent and selective interleukin mimetics

Publications (1)

Publication Number Publication Date
EA202092507A1 true EA202092507A1 (en) 2021-05-19

Family

ID=76160084

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202092507A EA202092507A1 (en) 2018-11-16 2019-06-24 DE NOVO MODELING OF EFFECTIVE AND SELECTIVE INTERLEUKIN MIMETICS

Country Status (1)

Country Link
EA (1) EA202092507A1 (en)

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