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Application filed by Страйдбайо, Инк.filedCriticalСтрайдбайо, Инк.
Priority claimed from PCT/US2019/025610external-prioritypatent/WO2019195444A1/en
Publication of EA202092353A1publicationCriticalpatent/EA202092353A1/en
В настоящем изобретении предложены капсидные белки AAV, содержащие модификацию в аминокислотной последовательности, и вирусные векторы, содержащие модифицированный капсидный белок AAV. В изобретении также предложены способы введения вирусных векторов и вирусных капсидов по изобретению в клетку или субъекту in vivo.The present invention provides AAV capsid proteins containing a modification in the amino acid sequence and viral vectors containing the modified AAV capsid protein. The invention also provides methods for introducing viral vectors and viral capsids of the invention into a cell or subject in vivo.
isolated virus, cell culture, gene encoding a protein, protein, DNA fragment, living recombinant vector virus, pseudo particle, vaccine, antibody or antiserum, method for preparing a vaccine, and, diagnostic test kit.