EA202092118A2 - COMPOSITIONS AND METHODS FOR INHIBITING TRANSTYRETIN EXPRESSION - Google Patents

COMPOSITIONS AND METHODS FOR INHIBITING TRANSTYRETIN EXPRESSION

Info

Publication number
EA202092118A2
EA202092118A2 EA202092118A EA202092118A EA202092118A2 EA 202092118 A2 EA202092118 A2 EA 202092118A2 EA 202092118 A EA202092118 A EA 202092118A EA 202092118 A EA202092118 A EA 202092118A EA 202092118 A2 EA202092118 A2 EA 202092118A2
Authority
EA
Eurasian Patent Office
Prior art keywords
methods
transtyretin
inhibiting
expression
compositions
Prior art date
Application number
EA202092118A
Other languages
Russian (ru)
Other versions
EA202092118A3 (en
Inventor
Динах Вен-Йи Сах
Грегори Хинкл
Рене Альварес
Стюарт Милстейн
Цинминь Чэнь
Original Assignee
Элнилэм Фармасьютикалз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Элнилэм Фармасьютикалз, Инк. filed Critical Элнилэм Фармасьютикалз, Инк.
Publication of EA202092118A2 publication Critical patent/EA202092118A2/en
Publication of EA202092118A3 publication Critical patent/EA202092118A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Данное изобретение относится к двухцепочечной рибонуклеиновой кислоте (дцРНК), поражающей ген транстиретина (TTR), и способам применения этой дцРНК для ингибирования TTR.This invention relates to a double-stranded ribonucleic acid (dsRNA) that attacks the transthyretin (TTR) gene and methods of using this dsRNA to inhibit TTR.

EA202092118A 2009-09-22 2009-10-20 COMPOSITIONS AND METHODS FOR INHIBITING TRANSTYRETIN EXPRESSION EA202092118A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US24479409P 2009-09-22 2009-09-22

Publications (2)

Publication Number Publication Date
EA202092118A2 true EA202092118A2 (en) 2020-12-30
EA202092118A3 EA202092118A3 (en) 2021-04-30

Family

ID=74100027

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202092118A EA202092118A3 (en) 2009-09-22 2009-10-20 COMPOSITIONS AND METHODS FOR INHIBITING TRANSTYRETIN EXPRESSION

Country Status (1)

Country Link
EA (1) EA202092118A3 (en)

Also Published As

Publication number Publication date
EA202092118A3 (en) 2021-04-30

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