EA202091704A1 - PYRROLOBENZODIAZEPINE-ANTIBODY CONJUGATES - Google Patents

PYRROLOBENZODIAZEPINE-ANTIBODY CONJUGATES

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Publication number
EA202091704A1
EA202091704A1 EA202091704A EA202091704A EA202091704A1 EA 202091704 A1 EA202091704 A1 EA 202091704A1 EA 202091704 A EA202091704 A EA 202091704A EA 202091704 A EA202091704 A EA 202091704A EA 202091704 A1 EA202091704 A1 EA 202091704A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pyrrolobenzodiazepine
antibody conjugates
antibody
formula
conjugates
Prior art date
Application number
EA202091704A
Other languages
Russian (ru)
Other versions
EA039826B1 (en
Inventor
Патрисиус Хендрикус Корнелис Ван Беркель
Original Assignee
Адс Терапьютикс Са
Медимьюн Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Адс Терапьютикс Са, Медимьюн Лимитед filed Critical Адс Терапьютикс Са
Priority claimed from PCT/EP2018/053163 external-priority patent/WO2018146189A1/en
Publication of EA202091704A1 publication Critical patent/EA202091704A1/en
Publication of EA039826B1 publication Critical patent/EA039826B1/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Конъюгат формулы (I) Ab-(DL)p, в которой Ab представляет собой антитело, которое связывается с AXL; DL представляет собой формулу (A).A conjugate of formula (I) Ab- (DL) p, in which Ab is an antibody that binds to AXL; DL is formula (A).

EA202091704A 2017-11-30 2018-02-08 Pyrrolobenzodiazepine-antibody conjugates EA039826B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1719906.8A GB201719906D0 (en) 2017-11-30 2017-11-30 Pyrrolobenzodiazepine-antibody conjugates
PCT/EP2018/053163 WO2018146189A1 (en) 2017-02-08 2018-02-08 Pyrrolobenzodiazepine-antibody conjugates

Publications (2)

Publication Number Publication Date
EA202091704A1 true EA202091704A1 (en) 2021-02-01
EA039826B1 EA039826B1 (en) 2022-03-17

Family

ID=60950314

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202091704A EA039826B1 (en) 2017-11-30 2018-02-08 Pyrrolobenzodiazepine-antibody conjugates

Country Status (2)

Country Link
EA (1) EA039826B1 (en)
GB (1) GB201719906D0 (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR102013027577A2 (en) * 2012-10-25 2016-03-29 Memorialsloan Kettering Cancer Ct method of detecting an increased axl or gas6 level and method of identifying an egfr inhibitor resistant cancer patient
ES2740907T3 (en) * 2014-10-03 2020-02-07 Synaffix Bv Sulfamide linker, conjugates thereof and preparation methods
GB201506409D0 (en) * 2015-04-15 2015-05-27 Williams David G And Berkel Patricius H C Van And Howard Philip W Humanized anti-axl antibodies and their conjugates

Also Published As

Publication number Publication date
GB201719906D0 (en) 2018-01-17
EA039826B1 (en) 2022-03-17

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