EA202091305A2 - PROTEINS BASED ON THE STRUCTURAL DOMAIN OF FIBRONEKTIN BINDING PCSK9 - Google Patents

PROTEINS BASED ON THE STRUCTURAL DOMAIN OF FIBRONEKTIN BINDING PCSK9

Info

Publication number
EA202091305A2
EA202091305A2 EA202091305A EA202091305A EA202091305A2 EA 202091305 A2 EA202091305 A2 EA 202091305A2 EA 202091305 A EA202091305 A EA 202091305A EA 202091305 A EA202091305 A EA 202091305A EA 202091305 A2 EA202091305 A2 EA 202091305A2
Authority
EA
Eurasian Patent Office
Prior art keywords
proteins
structural domain
fibronektin
proteins based
relates
Prior art date
Application number
EA202091305A
Other languages
Russian (ru)
Other versions
EA202091305A3 (en
Inventor
Рей Кампхаусен
Шерон Т. Клоад
Джонатан Х. Дэвис
Фабиенне М. Денхез
Амна Саеед-Коте
Даса Липовсек
Чи Менг Лоу
Трейси С. Митчел
Джинджер С. Ракестроу
Кэти А. Руссо
Чинг-Хсиунг Фредерик Ло
Боуман Миао
Рекс А. Паркер
Дори Ф. Ситкофф
Original Assignee
Бристол-Майерс Сквибб Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бристол-Майерс Сквибб Компани filed Critical Бристол-Майерс Сквибб Компани
Publication of EA202091305A2 publication Critical patent/EA202091305A2/en
Publication of EA202091305A3 publication Critical patent/EA202091305A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

Настоящее изобретение относится к белкам на основе структурного домена фибронектина, которые связывают PCSK9. Изобретение также относится к применению данных инновационных белков в терапевтических применениях для лечения атеросклероза, гиперхолистеринемии и других заболеваний, связанных с повышенным уровнем холестерина. Данное изобретение также относится к клеткам, содержащим данные белки, полинуклеотидам, кодирующим данные белки или их фрагменты, и векторам, содержащим данные полинуклеотиды, кодирующие данные инновационные белки.The present invention relates to proteins based on the structural domain of fibronectin that bind PCSK9. The invention also relates to the use of these innovative proteins in therapeutic applications for the treatment of atherosclerosis, hypercholesterolemia and other diseases associated with high cholesterol levels. This invention also relates to cells containing these proteins, polynucleotides encoding these proteins or fragments thereof, and vectors containing these polynucleotides encoding these innovative proteins.

EA202091305A 2010-05-03 2011-04-13 PROTEINS BASED ON THE STRUCTURAL DOMAIN OF FIBRONEKTIN BINDING PCSK9 EA202091305A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US33073110P 2010-05-03 2010-05-03

Publications (2)

Publication Number Publication Date
EA202091305A2 true EA202091305A2 (en) 2021-08-31
EA202091305A3 EA202091305A3 (en) 2021-10-29

Family

ID=77495433

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202091305A EA202091305A3 (en) 2010-05-03 2011-04-13 PROTEINS BASED ON THE STRUCTURAL DOMAIN OF FIBRONEKTIN BINDING PCSK9

Country Status (1)

Country Link
EA (1) EA202091305A3 (en)

Also Published As

Publication number Publication date
EA202091305A3 (en) 2021-10-29

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