EA202090782A1 - METHODS AND COMPOSITIONS FOR DETERMINING RESISTANCE TO THERAPY DIRECTED TO THE ANDROGEN RECEPTOR - Google Patents
METHODS AND COMPOSITIONS FOR DETERMINING RESISTANCE TO THERAPY DIRECTED TO THE ANDROGEN RECEPTORInfo
- Publication number
- EA202090782A1 EA202090782A1 EA202090782A EA202090782A EA202090782A1 EA 202090782 A1 EA202090782 A1 EA 202090782A1 EA 202090782 A EA202090782 A EA 202090782A EA 202090782 A EA202090782 A EA 202090782A EA 202090782 A1 EA202090782 A1 EA 202090782A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- androgen receptor
- methods
- modified
- compositions
- receptor polypeptides
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Reproductive Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
В настоящем изобретении описаны модифицированные полипептиды андрогенного рецептора, которые являются резистентными к ингибированию ингибитором андрогенного рецептора. В настоящем документе описаны композиции, комбинации и наборы, содержащие модифицированные полипептиды андрогенного рецептора, а также способы применения модифицированных полипептидов андрогенного рецептора. В настоящем документе также описаны способы применения модифицированных полипептидов андрогенного рецептора в качестве агентов скрининга для выявления и конструирования модуляторов андрогенного рецептора третьего поколения. В настоящем документе также описаны модуляторы андрогенного рецептора третьего поколения, которые ингибируют активность модифицированных полипептидов андрогенного рецептора. Также описаны фармацевтические композиции и лекарственные средства, которые включают описанные в настоящем документе соединения, а также способы применения таких модуляторов андрогенного рецептора самостоятельно или в комбинации с другими соединениями для лечения заболеваний или состояний, включая онкологические заболевания, такие как кастрационно-резистентный рак предстательной железы, которые опосредованы или зависят от андрогенных рецепторов.The present invention describes modified androgen receptor polypeptides that are resistant to inhibition by an androgen receptor inhibitor. This document describes compositions, combinations and kits containing modified androgen receptor polypeptides, as well as methods of using the modified androgen receptor polypeptides. Methods of using modified androgen receptor polypeptides as screening agents for the detection and design of third generation androgen receptor modulators are also described herein. This document also describes third generation androgen receptor modulators that inhibit the activity of modified androgen receptor polypeptides. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such androgen receptor modulators, alone or in combination with other compounds, to treat diseases or conditions, including cancers such as castration-resistant prostate cancer, which are mediated or dependent on androgen receptors.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361829123P | 2013-05-30 | 2013-05-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
EA202090782A1 true EA202090782A1 (en) | 2020-07-31 |
Family
ID=71833548
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA202090782A EA202090782A1 (en) | 2013-05-30 | 2013-07-26 | METHODS AND COMPOSITIONS FOR DETERMINING RESISTANCE TO THERAPY DIRECTED TO THE ANDROGEN RECEPTOR |
Country Status (1)
Country | Link |
---|---|
EA (1) | EA202090782A1 (en) |
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2013
- 2013-07-26 EA EA202090782A patent/EA202090782A1/en unknown
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