EA201992719A1 - Deuterated pyridone amides and their prodrugs as sodium channel modulators - Google Patents

Deuterated pyridone amides and their prodrugs as sodium channel modulators

Info

Publication number
EA201992719A1
EA201992719A1 EA201992719A EA201992719A EA201992719A1 EA 201992719 A1 EA201992719 A1 EA 201992719A1 EA 201992719 A EA201992719 A EA 201992719A EA 201992719 A EA201992719 A EA 201992719A EA 201992719 A1 EA201992719 A1 EA 201992719A1
Authority
EA
Eurasian Patent Office
Prior art keywords
sodium channel
deuterated
prodrugs
channel modulators
compounds
Prior art date
Application number
EA201992719A
Other languages
Russian (ru)
Inventor
Ликонг Джианг
Сара Сабина Хадида Руах
Original Assignee
Вертекс Фармасьютикалз Инкорпорейтед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Вертекс Фармасьютикалз Инкорпорейтед filed Critical Вертекс Фармасьютикалз Инкорпорейтед
Priority claimed from PCT/US2018/032939 external-priority patent/WO2018213426A1/en
Publication of EA201992719A1 publication Critical patent/EA201992719A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Предложены соединения и их фармацевтически приемлемые соли, используемые в качестве ингибиторов натриевых каналов. Соединения имеют формулугде R представляет собой H или CHOPO(OH). Предложены также фармацевтические композиции, содержащие соединения или фармацевтически приемлемые соли, и способы применения соединений, фармацевтически приемлемых солей и фармацевтических композиций при лечении различных расстройств, включая боль.Compounds and their pharmaceutically acceptable salts, useful as sodium channel inhibitors, are provided. The compounds have the formula where R represents H or CHOPO (OH). Also provided are pharmaceutical compositions containing the compounds or pharmaceutically acceptable salts, and methods for using the compounds, pharmaceutically acceptable salts and pharmaceutical compositions in the treatment of various disorders, including pain.

EA201992719A 2017-08-18 2018-05-16 Deuterated pyridone amides and their prodrugs as sodium channel modulators EA201992719A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762547718P 2017-08-18 2017-08-18
PCT/US2018/032939 WO2018213426A1 (en) 2017-05-16 2018-05-16 Deuterated pyridone amides and prodrugs thereof as modulators of sodium channels

Publications (1)

Publication Number Publication Date
EA201992719A1 true EA201992719A1 (en) 2020-03-18

Family

ID=69942864

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201992719A EA201992719A1 (en) 2017-08-18 2018-05-16 Deuterated pyridone amides and their prodrugs as sodium channel modulators

Country Status (1)

Country Link
EA (1) EA201992719A1 (en)

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