EA201992500A3 - Salts and Drugs of 1-Methyl-D-Tryptophan - Google Patents

Salts and Drugs of 1-Methyl-D-Tryptophan

Info

Publication number
EA201992500A3
EA201992500A3 EA201992500A EA201992500A EA201992500A3 EA 201992500 A3 EA201992500 A3 EA 201992500A3 EA 201992500 A EA201992500 A EA 201992500A EA 201992500 A EA201992500 A EA 201992500A EA 201992500 A3 EA201992500 A3 EA 201992500A3
Authority
EA
Eurasian Patent Office
Prior art keywords
salts
indoximod
tryptophan
drugs
methyl
Prior art date
Application number
EA201992500A
Other languages
Russian (ru)
Other versions
EA201992500A2 (en
Inventor
Марио Маутино
Санджив Кумар
Фироз Джайпури
Джесси Вальдо
Хима Поттури
Хун Чжуан
Original Assignee
Ньюлинк Дженетикс Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ньюлинк Дженетикс Корпорейшн filed Critical Ньюлинк Дженетикс Корпорейшн
Publication of EA201992500A2 publication Critical patent/EA201992500A2/en
Publication of EA201992500A3 publication Critical patent/EA201992500A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

В настоящее время представлены пролекарства и соли индоксимода и фармацевтические композиции, содержащие соли и пролекарства индоксимода, которые обеспечивают повышенную концентрацию в плазме и воздействие индоксимода по сравнению с прямым введением индоксимода у пациентов, нуждающихся в лечении иммуносупрессии, опосредованной индоламин-2,3-диоксигеназой, таких как больные раком или хроническими инфекционными заболеваниями.Currently, indoximod prodrugs and salts and pharmaceutical compositions are presented, containing indoximod salts and prodrugs that provide an increased plasma concentration and indoximode effect compared to the direct administration of indoximod in patients in need of treatment with immunosuppression mediated by indolamine-2,3-dioxygenase, such as cancer patients or chronic infectious diseases.

EA201992500A 2016-03-09 2016-06-02 Salts and Drugs of 1-Methyl-D-Tryptophan EA201992500A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662305748P 2016-03-09 2016-03-09

Publications (2)

Publication Number Publication Date
EA201992500A2 EA201992500A2 (en) 2020-02-28
EA201992500A3 true EA201992500A3 (en) 2020-05-31

Family

ID=69636688

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201992500A EA201992500A3 (en) 2016-03-09 2016-06-02 Salts and Drugs of 1-Methyl-D-Tryptophan

Country Status (1)

Country Link
EA (1) EA201992500A3 (en)

Also Published As

Publication number Publication date
EA201992500A2 (en) 2020-02-28

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