EA201992472A2 - SULFAMOILYPYRROLAMIDE DERIVATIVES AND THEIR APPLICATION AS MEDICINES FOR THE TREATMENT OF HEPATITIS B - Google Patents

SULFAMOILYPYRROLAMIDE DERIVATIVES AND THEIR APPLICATION AS MEDICINES FOR THE TREATMENT OF HEPATITIS B

Info

Publication number
EA201992472A2
EA201992472A2 EA201992472A EA201992472A EA201992472A2 EA 201992472 A2 EA201992472 A2 EA 201992472A2 EA 201992472 A EA201992472 A EA 201992472A EA 201992472 A EA201992472 A EA 201992472A EA 201992472 A2 EA201992472 A2 EA 201992472A2
Authority
EA
Eurasian Patent Office
Prior art keywords
sulfamoilypyrrolamide
hepatitis
medicines
derivatives
treatment
Prior art date
Application number
EA201992472A
Other languages
Russian (ru)
Other versions
EA201992472A3 (en
Inventor
Коэн Вандик
Жервен Ивонн Поль Аше
Стефан Жюльен Ласт
Дэвид Крейг Мак Гоуен
Герт Ромбу
Вим Гастон Версхюэрен
Пьер Жан-Мари Бернар Рабуассон
Original Assignee
Янссен Сайенсиз Айрлэнд Юси
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Янссен Сайенсиз Айрлэнд Юси filed Critical Янссен Сайенсиз Айрлэнд Юси
Publication of EA201992472A2 publication Critical patent/EA201992472A2/en
Publication of EA201992472A3 publication Critical patent/EA201992472A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Ингибиторы репликации HBV формулы (ID)в том числе их стереохимически изомерные формы, а также их соли, гидраты, сольваты, где X, R-Rи R-Rимеют значения, определенные в настоящем документе. Настоящее изобретение также относится к способам получения указанных соединений, к содержащим их фармацевтическим композициям, а также к их применению отдельно или в комбинации с другими ингибиторами HBV в терапии, активной против HBV.HBV replication inhibitors of formula (ID) including their stereochemically isomeric forms, as well as their salts, hydrates, solvates, where X, R-R and R-R are as defined herein. The present invention also relates to methods for producing these compounds, to pharmaceutical compositions containing them, as well as to their use alone or in combination with other HBV inhibitors in anti-HBV therapy.

EA201992472A 2014-03-05 2014-05-16 SULFAMOILYPYROROLAMIDE DERIVATIVES AND THEIR APPLICATION AS MEDICINES FOR THE TREATMENT OF HEPATITIS B EA201992472A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP14157900 2014-03-05

Publications (2)

Publication Number Publication Date
EA201992472A2 true EA201992472A2 (en) 2020-02-28
EA201992472A3 EA201992472A3 (en) 2020-06-30

Family

ID=50230967

Family Applications (3)

Application Number Title Priority Date Filing Date
EA201992472A EA201992472A3 (en) 2014-03-05 2014-05-16 SULFAMOILYPYROROLAMIDE DERIVATIVES AND THEIR APPLICATION AS MEDICINES FOR THE TREATMENT OF HEPATITIS B
EA202092842A EA202092842A3 (en) 2014-03-05 2014-05-16 SULFAMOYLPYRROLAMIDE DERIVATIVES AND THEIR USE AS MEDICINES FOR THE TREATMENT OF HEPATITIS B
EA201992471A EA201992471A3 (en) 2014-03-05 2014-05-16 SULFAMOILYPYROROLAMIDE DERIVATIVES AND THEIR APPLICATION AS MEDICINES FOR THE TREATMENT OF HEPATITIS B

Family Applications After (2)

Application Number Title Priority Date Filing Date
EA202092842A EA202092842A3 (en) 2014-03-05 2014-05-16 SULFAMOYLPYRROLAMIDE DERIVATIVES AND THEIR USE AS MEDICINES FOR THE TREATMENT OF HEPATITIS B
EA201992471A EA201992471A3 (en) 2014-03-05 2014-05-16 SULFAMOILYPYROROLAMIDE DERIVATIVES AND THEIR APPLICATION AS MEDICINES FOR THE TREATMENT OF HEPATITIS B

Country Status (1)

Country Link
EA (3) EA201992472A3 (en)

Also Published As

Publication number Publication date
EA201992472A3 (en) 2020-06-30
EA201992471A2 (en) 2020-02-28
EA202092842A2 (en) 2021-04-30
EA202092842A3 (en) 2021-06-30
EA201992471A3 (en) 2020-06-30

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