EA201992455A2 - METHODS FOR SYNTHESIS OF ANALOGUE OF PROSTATSIKLIN - Google Patents

METHODS FOR SYNTHESIS OF ANALOGUE OF PROSTATSIKLIN

Info

Publication number
EA201992455A2
EA201992455A2 EA201992455A EA201992455A EA201992455A2 EA 201992455 A2 EA201992455 A2 EA 201992455A2 EA 201992455 A EA201992455 A EA 201992455A EA 201992455 A EA201992455 A EA 201992455A EA 201992455 A2 EA201992455 A2 EA 201992455A2
Authority
EA
Eurasian Patent Office
Prior art keywords
methods
present
compound
formula
provides
Prior art date
Application number
EA201992455A
Other languages
Russian (ru)
Other versions
EA201992455A3 (en
Inventor
Кирк Уилльям Херинг
Жилль Шамбурнье
Грегори Уилльям Эндрес
Виктор Федий
Томас Джеймс II Крелл
Хуссейн Махмуд Махмуд
Original Assignee
Кайман Кемикал Компани Инкорпорейтед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Кайман Кемикал Компани Инкорпорейтед filed Critical Кайман Кемикал Компани Инкорпорейтед
Publication of EA201992455A2 publication Critical patent/EA201992455A2/en
Publication of EA201992455A3 publication Critical patent/EA201992455A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D301/00—Preparation of oxiranes
    • C07D301/32—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Настоящее изобретение предлагает соединение формулы 1а и способ его очистки. Также изобретение предлагает способ получения соединения формулы 5, где каждый Rнезависимо выбирают из Cалкила или фенила. Способы данного изобретения включают стадии, которые позволяют получать улучшенные выходы и меньше побочных продуктов, чем в традиционных способах. В способах данного изобретения применяются реагенты (например, реагенты-окислители), которые менее токсичны, чем те, которые используются в традиционных способах (например, оксалил хлорид). Со способами настоящего изобретения получают соединения с улучшенными показателями э.и. и химической чистоты; таким образом устраняется необходимость использования дополнительных хроматографических стадий. А также, способы данного изобретения пригодны для масштабирования процессов получения коммерческих количеств конечного продукта.The present invention provides a compound of formula 1a and a method for its purification. The invention also provides a process for preparing a compound of formula 5, wherein each R is independently selected from C1-6alkyl or phenyl. The methods of the invention include steps that provide improved yields and fewer by-products than conventional methods. The methods of the present invention employ reagents (e.g., oxidizing agents) that are less toxic than those used in conventional methods (e.g., oxalyl chloride). With the methods of the present invention, compounds with improved e.i. and chemical purity; thus eliminating the need for additional chromatographic steps. And also, the methods of this invention are suitable for scaling the processes of obtaining commercial quantities of the final product.

EA201992455A 2013-03-12 2013-12-06 METHODS FOR SYNTHESIS OF ANALOGUE OF PROSTATSIKLIN EA201992455A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361777882P 2013-03-12 2013-03-12

Publications (2)

Publication Number Publication Date
EA201992455A2 true EA201992455A2 (en) 2020-02-28
EA201992455A3 EA201992455A3 (en) 2020-05-31

Family

ID=69636694

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201992455A EA201992455A3 (en) 2013-03-12 2013-12-06 METHODS FOR SYNTHESIS OF ANALOGUE OF PROSTATSIKLIN

Country Status (1)

Country Link
EA (1) EA201992455A3 (en)

Also Published As

Publication number Publication date
EA201992455A3 (en) 2020-05-31

Similar Documents

Publication Publication Date Title
EA202090917A1 (en) OBTAINING PSILOCYBIN, DIFFERENT POLYMORPHOUS FORMS, INTERMEDIATE COMPOUNDS, COMPOSITIONS AND THEIR APPLICATION
EA201591093A1 (en) METHODS OF SYNTHESIS ANALOGUE OF PROSTACYCLINE
MX2019012942A (en) Fused imidazo-piperidine jak inhibitor compound.
CY1121395T1 (en) TETRAHYDROPYRIDOPYRAZINES-FORMERS TOY GPR6
EA201790916A1 (en) NEW RIG-I LIGANDS AND METHODS OF THEIR RECEPTION
MX2018014164A (en) Intermediates for the synthesis of bile acid derivatives, in particular of obeticholic acid.
EA201301315A1 (en) METHOD FOR OBTAINING INTERMEDIATE COMPOUNDS OF ESTHETROL
MX2021011971A (en) Process for the preparation of substituted cycloserines.
EA201490438A1 (en) ANTIBACTERIAL 3,4-DIHYDRO-1N- [1,8] NAFTYRIDINONES, SUBSTITUTED BY CYCLOPENT [C] PIRROL
MX2018014128A (en) Steroid 6.7.beta.-epoxides as chemical intermediates.
NZ707276A (en) Compounds useful in the synthesis of benzamide compounds
EA202091466A1 (en) SYNTHESIS OF SOCRYSTAL 1: 1: 1 1-CIANO-2- (4-CYCLOPROPYLBENZYL) -4 - (- D-GLUCOPYRANOSE-1-YL) BENZENE, L-PROLINE AND WATER
BR112017020484A2 (en) The manufacturing methods and those producing intermediates of a new nitrogen-containing compound or its salt
EP3784649A4 (en) Process for the synthesis of (s)-3-amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid
EA201490436A1 (en) ANTIBACTERIAL 3,4-DIHYDRO-1N- [1,8] NAFTYRIDINOES FURNISHED BY HOMOPIPERIDINIL
MX2022005229A (en) An efficient new process for synthesis of 2-amino-5-chloro-n-,3-d imethylbenzamide.
EA202090933A1 (en) METHOD FOR PREPARING HERBICIDAL PYRIDAZINONE COMPOUNDS
EA201391721A1 (en) METHOD OF OBTAINING POLYMORPHIC FORM I ETHORIKOXIB
EA201690467A1 (en) INDUSTRIAL METHOD FOR SYNTHESIS OF APSETATE PLATESTRATE AND ITS 4'-ACETYL ANALOGUE
EA201992455A2 (en) METHODS FOR SYNTHESIS OF ANALOGUE OF PROSTATSIKLIN
MX2021004288A (en) New process for the synthesis of piperazinyl-ethoxy-bromophenyl derivates and their application in the production of compounds containing them.
MA41186A (en) NEW FORAMSULFURON MONOSODIUM SALT CRYSTAL FORMS
MX2021013507A (en) Process for the preparation of clc-1 chloride channel inhibitors.
TR201902673T4 (en) Processes for the preparation of compounds useful in the synthesis of medetomidine, such as 3-arylbutanes.
EA201791098A1 (en) METHOD FOR SYNTHESIS OF BENZAZEPIN DERIVATIVES