EA201992410A2 - TROPOMYOSIN-DEPENDENT KINASE INHIBITORS (Trk) - Google Patents
TROPOMYOSIN-DEPENDENT KINASE INHIBITORS (Trk)Info
- Publication number
- EA201992410A2 EA201992410A2 EA201992410A EA201992410A EA201992410A2 EA 201992410 A2 EA201992410 A2 EA 201992410A2 EA 201992410 A EA201992410 A EA 201992410A EA 201992410 A EA201992410 A EA 201992410A EA 201992410 A2 EA201992410 A2 EA 201992410A2
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- tropomyosin
- dependent kinase
- trk
- inhibitors
- trk inhibitors
- Prior art date
Links
- 229940043355 kinase inhibitor Drugs 0.000 title abstract 2
- 239000003757 phosphotransferase inhibitor Substances 0.000 title abstract 2
- 102000005937 Tropomyosin Human genes 0.000 abstract 4
- 108010030743 Tropomyosin Proteins 0.000 abstract 4
- 230000001419 dependent effect Effects 0.000 abstract 4
- 239000003112 inhibitor Substances 0.000 abstract 4
- 108091000080 Phosphotransferase Proteins 0.000 abstract 3
- 201000008482 osteoarthritis Diseases 0.000 abstract 3
- 102000020233 phosphotransferase Human genes 0.000 abstract 3
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 102000007651 Macrophage Colony-Stimulating Factor Human genes 0.000 abstract 1
- 108010046938 Macrophage Colony-Stimulating Factor Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 208000030159 metabolic disease Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- -1 small molecule compounds Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/50—Organo-phosphines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Ингибиторы тропомиозин-зависимых киназ (Trk-ингибиторы) являются соединениями-малыми молекулами, пригодными в лечении заболевания. Trk-ингибиторы можно применять в качестве фармацевтических средств и в фармацевтических композициях. Trk-ингибиторы пригодны в лечении воспалительных заболеваний, аутоиммунного заболевания, нарушений метаболизма в костной ткани и/или рака и особенно пригодны в лечении остеоартрита (OA), боли и связанной с OA боли. Trk-ингибиторы также пригодны для ингибирования тропомиозин-зависимой киназы A (TrkA), тропомиозин-зависимой киназы B (TrkB), тропомиозин-зависимой киназы C (TrkC) и/или c-FMS (клеточного рецептора для колониестимулирующего фактора-1 (CSF-1)).Tropomyosin-dependent kinase inhibitors (Trk inhibitors) are small molecule compounds useful in treating a disease. Trk inhibitors can be used as pharmaceuticals and in pharmaceutical compositions. Trk inhibitors are useful in the treatment of inflammatory diseases, autoimmune diseases, metabolic disorders in bone tissue and / or cancer, and are particularly useful in the treatment of osteoarthritis (OA), pain and OA-related pain. Trk inhibitors are also suitable for inhibiting tropomyosin-dependent kinase A (TrkA), tropomyosin-dependent kinase B (TrkB), tropomyosin-dependent kinase C (TrkC) and / or c-FMS (cell receptor for colony stimulating factor-1 (CSF- 1)).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462040750P | 2014-08-22 | 2014-08-22 |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201992410A2 true EA201992410A2 (en) | 2020-02-28 |
EA201992410A3 EA201992410A3 (en) | 2020-05-31 |
Family
ID=69636691
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201992410A EA201992410A3 (en) | 2014-08-22 | 2014-12-10 | TROPOMYOSIN-DEPENDENT KINASE (TRK) INHIBITORS |
Country Status (1)
Country | Link |
---|---|
EA (1) | EA201992410A3 (en) |
-
2014
- 2014-12-10 EA EA201992410A patent/EA201992410A3/en unknown
Also Published As
Publication number | Publication date |
---|---|
EA201992410A3 (en) | 2020-05-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA201691196A1 (en) | TROPOMYOSIN-DEPENDENT KINAZ INHIBITORS (TRK) | |
EA201991399A1 (en) | AMINOTRIAZOLOPYRIDINE COMPOUNDS AND THEIR APPLICATION IN TREATMENT OF CANCER | |
EA201890725A1 (en) | PHARNESIDE X-RECEPTOR AGONISTS AND THEIR APPLICATION | |
SA518391624B1 (en) | Modulators of ROR-GAMMA | |
EA201691151A1 (en) | CONNECTIONS FOR THE TREATMENT OF PATIENTS WITH ROS1-MUTANT CANCER CELLS | |
EA201790492A1 (en) | CONNECTIONS THAT INHIBIT McL-1 PROTEIN | |
EA201792047A1 (en) | NEW CONNECTIONS | |
EA201791018A1 (en) | DERIVATIVES OF 6-AMINO-7-BICYCLO-7-DEAZAPURIN AS PROTECTINININASE INHIBITORS | |
EA201691516A1 (en) | DIHYDROPYRROLOPIRIDINOVYY INHIBITORS ROR-GAMMA | |
EA201790078A1 (en) | MNK INHIBITORS AND RELATED METHODS | |
EA201390772A1 (en) | NEW SALTS AND POLYMORPHIC FORMS OF AFATINIBA | |
EA201391682A1 (en) | SUBSTITUTED DERIVATIVES OF INDAZOLS ACTIVE AS KINASE INHIBITORS | |
EA201691940A1 (en) | NEW CONNECTIONS | |
EA201590855A1 (en) | COMPOUNDS OF PYRROPOLYMIDININE AS KINAZ INHIBITORS | |
EA201500394A1 (en) | INHIBITORS DISTEMYLASE HYSTONES | |
EA201792304A1 (en) | COMBINED THERAPY FOR CANCER TREATMENT | |
EA201290103A1 (en) | HETEROCYCLIC COMPOUNDS AND THEIR USE | |
EA201891399A1 (en) | BIPIRAZOLE DERIVATIVES, SUITABLE FOR THE TREATMENT OF AUTOIMMUNE DISEASES | |
EA201201661A1 (en) | NEW AMINOPYRAZOLOHINAZOLINES | |
EA201790519A1 (en) | THERAPEUTIC CONNECTIONS AS INTEGRATORS OF OREXIN-1 RECEPTOR | |
JOP20200230A1 (en) | Ppar agonists, compounds, pharmaceutical compositions, and methods of use thereof | |
EA202190588A1 (en) | HETEROAROMATIC COMPOUNDS AS VANIN INHIBITORS | |
EA202191478A1 (en) | HETEROAROMATIC COMPOUNDS AS VANIN INHIBITORS | |
EA201891710A1 (en) | THERAPEUTIC CONNECTIONS | |
EA201790253A1 (en) | ALDOSTERONSYNTASE INHIBITORS |