EA201992295A1 - Derivatives of mono- or disubstituted indoles as inhibitors of replication of virus viruses - Google Patents

Derivatives of mono- or disubstituted indoles as inhibitors of replication of virus viruses

Info

Publication number
EA201992295A1
EA201992295A1 EA201992295A EA201992295A EA201992295A1 EA 201992295 A1 EA201992295 A1 EA 201992295A1 EA 201992295 A EA201992295 A EA 201992295A EA 201992295 A EA201992295 A EA 201992295A EA 201992295 A1 EA201992295 A1 EA 201992295A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compounds
mono
replication
inhibitors
derivatives
Prior art date
Application number
EA201992295A
Other languages
Russian (ru)
Inventor
Барт Рудольф Романи Кестелейн
Жан-Франсуа Бонфанти
Тим Хьюго Мария Йонкерс
Пьер Жан-Мари Бернар Рабуассон
Дороте Алис Мари-Эв Бардио
Арно Дидье М Маршан
Original Assignee
Янссен Фармасьютикалз, Инк.
Католике Университейт Левен
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Янссен Фармасьютикалз, Инк., Католике Университейт Левен filed Critical Янссен Фармасьютикалз, Инк.
Publication of EA201992295A1 publication Critical patent/EA201992295A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Настоящее изобретение относится к соединениям моно- или дизамещенных индолов, способам предупреждения или лечения вирусной инфекции денге посредством применения указанных соединений, а также относится к указанным соединениям для применения в качестве лекарственного средства, более предпочтительно для применения в качестве лекарственного средства для лечения или предупреждения вирусной инфекции денге. Настоящее изобретение дополнительно относится к фармацевтическим композициям или комбинированным препаратам на основе соединений, к композициям или препаратам для применения в качестве лекарственного средства, более предпочтительно для предупреждения или лечения вирусной инфекции денге. Настоящее изобретение также относится к способам получения таких соединений.The present invention relates to compounds of mono- or disubstituted indoles, methods of preventing or treating a viral dengue infection by using said compounds, and also relates to said compounds for use as a medicine, more preferably for use as a medicine for the treatment or prevention of a viral infection dengue. The present invention further relates to pharmaceutical compositions or combination preparations based on compounds, to compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infection. The present invention also relates to methods for the preparation of such compounds.

EA201992295A 2016-03-31 2016-05-04 Derivatives of mono- or disubstituted indoles as inhibitors of replication of virus viruses EA201992295A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP16163342 2016-03-31

Publications (1)

Publication Number Publication Date
EA201992295A1 true EA201992295A1 (en) 2020-05-31

Family

ID=55650293

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201992295A EA201992295A1 (en) 2016-03-31 2016-05-04 Derivatives of mono- or disubstituted indoles as inhibitors of replication of virus viruses

Country Status (2)

Country Link
EA (1) EA201992295A1 (en)
PT (1) PT3294738T (en)

Also Published As

Publication number Publication date
PT3294738T (en) 2021-06-30

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